Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats

Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. This baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an impor-tant role in baroreflex function.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalJournal of Pharmacological Sciences
Volume112
Issue number4
DOIs
Publication statusPublished - Apr 16 2010

Fingerprint

Solitary Nucleus
Baroreflex
Aldosterone
Sodium
Neurons
11-beta-Hydroxysteroid Dehydrogenases
Mineralocorticoid Receptor Antagonists
Mineralocorticoid Receptors
Microinjections
Phenylephrine

Keywords

  • Aldosterone-sensitive nucleus tractus solitarius (NTS) neuron
  • Arterial baroreceptor reflex
  • Mineralocorticoid (MR) antagonist eplerenone

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats. / Masuda, Tomoharu; Hirabara, Yasutoshi; Nakamura, Yusuke; Chishaki, Akiko; Tsuruhisa, Mai; Miyakawa, Masayuki; Honda, Kenji; Saito, Ryo; Sakamoto, Hirotaka; Kawata, Mitsuhiro; Takano, Yukio.

In: Journal of Pharmacological Sciences, Vol. 112, No. 4, 16.04.2010, p. 482-486.

Research output: Contribution to journalArticle

Masuda, T, Hirabara, Y, Nakamura, Y, Chishaki, A, Tsuruhisa, M, Miyakawa, M, Honda, K, Saito, R, Sakamoto, H, Kawata, M & Takano, Y 2010, 'Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats', Journal of Pharmacological Sciences, vol. 112, no. 4, pp. 482-486. https://doi.org/10.1254/jphs.09362SC
Masuda, Tomoharu ; Hirabara, Yasutoshi ; Nakamura, Yusuke ; Chishaki, Akiko ; Tsuruhisa, Mai ; Miyakawa, Masayuki ; Honda, Kenji ; Saito, Ryo ; Sakamoto, Hirotaka ; Kawata, Mitsuhiro ; Takano, Yukio. / Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats. In: Journal of Pharmacological Sciences. 2010 ; Vol. 112, No. 4. pp. 482-486.
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