Alcohol consumption appears to protect against non-alcoholic fatty liver disease

A. Moriya, Yoshiaki Iwasaki, S. Ohguchi, E. Kayashima, T. Mitsumune, H. Taniguchi, Fusao Ikeda, Y. Shiratori, K. Yamamoto

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Abstract

Background Moderate alcohol consumption may have certain beneficial effects against non-alcoholic fatty liver disease, which is associated with metabolic syndrome. Aim To determine the association between drinking pattern and fatty liver in Japanese men and women. Methods A cross-sectional study was performed with health checkup data including information concerning alcohol consumption and ultrasonographic assessment of fatty liver. Results We analysed 4957 men and 2155 women without reported liver diseases (median age, 49 years). In men, 40% of nondrinkers and 28% of drinkers had fatty liver. Alcohol consumption was inversely associated with fatty liver (adjusted odds ratio, 0.54; 95% confidence interval, 0.46-0.63). The prevalence of fatty liver in each category of drinking frequency was 38% (1-3 days/week), 29% (4-6 days/week), and 24% (daily drinking); there was a significant inverse correlation between drinking frequency and the prevalence of fatty liver (P <0.001). In women, 16% of nondrinkers and 10% of drinkers had fatty liver. Drinking less than 20 g on 1-3 days/week was associated with low prevalence of fatty liver (adjusted odds ratio, 0.47; 95% confidence interval, 0.23-0.96). Conclusions Alcohol consumption appears to protect against non-alcoholic fatty liver disease.

Original languageEnglish
Pages (from-to)378-388
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume33
Issue number3
DOIs
Publication statusPublished - Feb 2011

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Fatty Liver
Alcohol Drinking
Drinking
Odds Ratio
Confidence Intervals
Non-alcoholic Fatty Liver Disease
Liver Diseases
Cross-Sectional Studies
Health

ASJC Scopus subject areas

  • Pharmacology (medical)

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Alcohol consumption appears to protect against non-alcoholic fatty liver disease. / Moriya, A.; Iwasaki, Yoshiaki; Ohguchi, S.; Kayashima, E.; Mitsumune, T.; Taniguchi, H.; Ikeda, Fusao; Shiratori, Y.; Yamamoto, K.

In: Alimentary Pharmacology and Therapeutics, Vol. 33, No. 3, 02.2011, p. 378-388.

Research output: Contribution to journalArticle

Moriya, A, Iwasaki, Y, Ohguchi, S, Kayashima, E, Mitsumune, T, Taniguchi, H, Ikeda, F, Shiratori, Y & Yamamoto, K 2011, 'Alcohol consumption appears to protect against non-alcoholic fatty liver disease', Alimentary Pharmacology and Therapeutics, vol. 33, no. 3, pp. 378-388. https://doi.org/10.1111/j.1365-2036.2010.04520.x
Moriya, A. ; Iwasaki, Yoshiaki ; Ohguchi, S. ; Kayashima, E. ; Mitsumune, T. ; Taniguchi, H. ; Ikeda, Fusao ; Shiratori, Y. ; Yamamoto, K. / Alcohol consumption appears to protect against non-alcoholic fatty liver disease. In: Alimentary Pharmacology and Therapeutics. 2011 ; Vol. 33, No. 3. pp. 378-388.
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