Albino and pale green 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana

Yoshiteru Noutoshi; Takuya Ito; Kazuo Shinozaki

doi:10.1093/pcp/pci119

Albino and pale green 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana

Yoshiteru Noutoshi, Takuya Ito, Kazuo Shinozaki

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We isolated an Arabidopsis albino and pale green 10 (apg10) mutant which exhibits pale green cotyledons and true leaves at the juvenile stage. We identified a valine to leucine change in BBMII (N′-[(5′- phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) isomerase involved in histidine biosynthesis. The morphological abnormality of apg10 was recovered by histidine supplementation. The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. We also revealed that the APG10 knockout mutant exhibited embryo lethality, indicating the essential role of the Arabidopsis BBMII isomerase for plant growth. JSPP

Original language	English
Pages (from-to)	1165-1172
Number of pages	8
Journal	Plant and Cell Physiology
Volume	46
Issue number	7
DOIs	https://doi.org/10.1093/pcp/pci119
Publication status	Published - Jul 2005
Externally published	Yes

Keywords

Albino and pale green mutant
Arabidopsis thaliana
BBMII isomerase
Histidine biosynthesis

ASJC Scopus subject areas

Physiology
Plant Science
Cell Biology

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10.1093/pcp/pci119

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title = "Albino and pale green 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana",

abstract = "We isolated an Arabidopsis albino and pale green 10 (apg10) mutant which exhibits pale green cotyledons and true leaves at the juvenile stage. We identified a valine to leucine change in BBMII (N′-[(5′- phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) isomerase involved in histidine biosynthesis. The morphological abnormality of apg10 was recovered by histidine supplementation. The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. We also revealed that the APG10 knockout mutant exhibited embryo lethality, indicating the essential role of the Arabidopsis BBMII isomerase for plant growth. JSPP",

keywords = "Albino and pale green mutant, Arabidopsis thaliana, BBMII isomerase, Histidine biosynthesis",

author = "Yoshiteru Noutoshi and Takuya Ito and Kazuo Shinozaki",

note = "Funding Information: We thank H. Morishita (RIKEN RRC) for amino acid measurements, and R. Motohashi for designation of the mutant. This work was supported in part by the Program for Promotion of Basic Research Activities for Innovative Biosciences (BRAIN) and the Special Coordination Fund of the Science and Technology Agency to K.S. Y.N. was supported by a postdoctoral fellowship from the Special Postdoctoral Researchers{\textquoteright} Program of RIKEN.",

year = "2005",

month = jul,

doi = "10.1093/pcp/pci119",

language = "English",

volume = "46",

pages = "1165--1172",

journal = "Plant and Cell Physiology",

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publisher = "Oxford University Press",

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T1 - Albino and pale green 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana

AU - Noutoshi, Yoshiteru

AU - Ito, Takuya

AU - Shinozaki, Kazuo

N1 - Funding Information: We thank H. Morishita (RIKEN RRC) for amino acid measurements, and R. Motohashi for designation of the mutant. This work was supported in part by the Program for Promotion of Basic Research Activities for Innovative Biosciences (BRAIN) and the Special Coordination Fund of the Science and Technology Agency to K.S. Y.N. was supported by a postdoctoral fellowship from the Special Postdoctoral Researchers’ Program of RIKEN.

PY - 2005/7

Y1 - 2005/7

N2 - We isolated an Arabidopsis albino and pale green 10 (apg10) mutant which exhibits pale green cotyledons and true leaves at the juvenile stage. We identified a valine to leucine change in BBMII (N′-[(5′- phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) isomerase involved in histidine biosynthesis. The morphological abnormality of apg10 was recovered by histidine supplementation. The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. We also revealed that the APG10 knockout mutant exhibited embryo lethality, indicating the essential role of the Arabidopsis BBMII isomerase for plant growth. JSPP

AB - We isolated an Arabidopsis albino and pale green 10 (apg10) mutant which exhibits pale green cotyledons and true leaves at the juvenile stage. We identified a valine to leucine change in BBMII (N′-[(5′- phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) isomerase involved in histidine biosynthesis. The morphological abnormality of apg10 was recovered by histidine supplementation. The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. We also revealed that the APG10 knockout mutant exhibited embryo lethality, indicating the essential role of the Arabidopsis BBMII isomerase for plant growth. JSPP

KW - Albino and pale green mutant

KW - Arabidopsis thaliana

KW - BBMII isomerase

KW - Histidine biosynthesis

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DO - 10.1093/pcp/pci119

M3 - Article

C2 - 15870096

AN - SCOPUS:25444434627

SN - 0032-0781

VL - 46

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EP - 1172

JO - Plant and Cell Physiology

JF - Plant and Cell Physiology

IS - 7

ER -

Albino and pale green 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana

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Keywords

ASJC Scopus subject areas

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