Airway hyperresponsiveness through synergy of γδ T cells and NKT cells

Niyun Jin, Nobuaki Miyahara, Christina L. Roark, Jena D. French, M. Kemal Aydintug, Jennifer L. Matsuda, Laurent Gapin, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Mice sensitized and challenged with OVA were used to investigate the role of innate T cells in the development of allergic airway hyperresponsiveness (AHR). AHR, but not eosinophilic airway inflammation, was induced in T cell-deficient mice by small numbers of cotransferred γδ T cells and invariant NKT cells, whereas either cell type alone was not effective. Only Vγ1+Vδ5+ γδ T cells enhanced AHR. Surprisingly, OVA-specific αβ T cells were not required, revealing a pathway of AHR development mediated entirely by innate T cells. The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses.

Original languageEnglish
Pages (from-to)2961-2968
Number of pages8
JournalJournal of Immunology
Volume179
Issue number5
DOIs
Publication statusPublished - Sep 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Jin, N., Miyahara, N., Roark, C. L., French, J. D., Aydintug, M. K., Matsuda, J. L., Gapin, L., O'Brien, R. L., Gelfand, E. W., & Born, W. K. (2007). Airway hyperresponsiveness through synergy of γδ T cells and NKT cells. Journal of Immunology, 179(5), 2961-2968. https://doi.org/10.4049/jimmunol.179.5.2961