Abstract
Germinal-vesicle (GV) transfer, spindle-chromosome complex transfer in metaphase-II oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial diseases. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. The present study used a new method based on the transfer of aggregated chromosomes, which occurs in human oocytes, before the metaphase spindle is established.
| Original language | English |
|---|---|
| Pages (from-to) | 401-404 |
| Number of pages | 4 |
| Journal | Reproductive BioMedicine Online |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2014 |
| Externally published | Yes |
Keywords
- aggregated chromosomes
- aneuploidy
- heteroplasmy
- microinjection
- mitochondrial disease
- nuclear transfer
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
- Developmental Biology
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Cite this
Otsuki, J., Nagai, Y., & Sankai, T. (2014). Aggregated chromosomes transfer in human oocytes. Reproductive BioMedicine Online, 28(3), 401-404. https://doi.org/10.1016/j.rbmo.2013.10.024