Aggregated chromosomes transfer in human oocytes

Junko Otsuki, Yasushi Nagai, Tadashi Sankai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Germinal-vesicle (GV) transfer, spindle-chromosome complex transfer in metaphase-II oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial diseases. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. The present study used a new method based on the transfer of aggregated chromosomes, which occurs in human oocytes, before the metaphase spindle is established.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalReproductive BioMedicine Online
Volume28
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Metaphase
Oocytes
Chromosomes
Mitochondrial Diseases
Aneuploidy
Therapeutics

Keywords

  • aggregated chromosomes
  • aneuploidy
  • heteroplasmy
  • microinjection
  • mitochondrial disease
  • nuclear transfer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

Cite this

Aggregated chromosomes transfer in human oocytes. / Otsuki, Junko; Nagai, Yasushi; Sankai, Tadashi.

In: Reproductive BioMedicine Online, Vol. 28, No. 3, 2014, p. 401-404.

Research output: Contribution to journalArticle

Otsuki, Junko ; Nagai, Yasushi ; Sankai, Tadashi. / Aggregated chromosomes transfer in human oocytes. In: Reproductive BioMedicine Online. 2014 ; Vol. 28, No. 3. pp. 401-404.
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