Aggravation of inflammatory bowel diseases by oral streptococci

A. Kojima, R. Nomura, Shuhei Naka, R. Okawa, T. Ooshima, K. Nakano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalOral Diseases
Volume20
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Keywords

  • Bacteraemia
  • Inflammatory bowel diseases
  • Interferon-gamma
  • Liver
  • Oral streptococci

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology
  • Medicine(all)

Cite this

Kojima, A., Nomura, R., Naka, S., Okawa, R., Ooshima, T., & Nakano, K. (2014). Aggravation of inflammatory bowel diseases by oral streptococci. Oral Diseases, 20(4), 359-366. https://doi.org/10.1111/odi.12125