Aggravation of inflammatory bowel diseases by oral streptococci

A. Kojima, R. Nomura, Shuhei Naka, R. Okawa, T. Ooshima, K. Nakano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalOral Diseases
Volume20
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Colitis
Streptococcus
Inflammatory Bowel Diseases
Interferons
Dextran Sulfate
Hepatocytes
Streptococcus mutans
Antibodies
Phagocytosis
Intravenous Administration
Virulence
Infection

Keywords

  • Bacteraemia
  • Inflammatory bowel diseases
  • Interferon-gamma
  • Liver
  • Oral streptococci

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology
  • Medicine(all)

Cite this

Kojima, A., Nomura, R., Naka, S., Okawa, R., Ooshima, T., & Nakano, K. (2014). Aggravation of inflammatory bowel diseases by oral streptococci. Oral Diseases, 20(4), 359-366. https://doi.org/10.1111/odi.12125

Aggravation of inflammatory bowel diseases by oral streptococci. / Kojima, A.; Nomura, R.; Naka, Shuhei; Okawa, R.; Ooshima, T.; Nakano, K.

In: Oral Diseases, Vol. 20, No. 4, 2014, p. 359-366.

Research output: Contribution to journalArticle

Kojima, A, Nomura, R, Naka, S, Okawa, R, Ooshima, T & Nakano, K 2014, 'Aggravation of inflammatory bowel diseases by oral streptococci', Oral Diseases, vol. 20, no. 4, pp. 359-366. https://doi.org/10.1111/odi.12125
Kojima, A. ; Nomura, R. ; Naka, Shuhei ; Okawa, R. ; Ooshima, T. ; Nakano, K. / Aggravation of inflammatory bowel diseases by oral streptococci. In: Oral Diseases. 2014 ; Vol. 20, No. 4. pp. 359-366.
@article{1fc20869831f421e828efbde544cad5c,
title = "Aggravation of inflammatory bowel diseases by oral streptococci",
abstract = "Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.",
keywords = "Bacteraemia, Inflammatory bowel diseases, Interferon-gamma, Liver, Oral streptococci",
author = "A. Kojima and R. Nomura and Shuhei Naka and R. Okawa and T. Ooshima and K. Nakano",
year = "2014",
doi = "10.1111/odi.12125",
language = "English",
volume = "20",
pages = "359--366",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Aggravation of inflammatory bowel diseases by oral streptococci

AU - Kojima, A.

AU - Nomura, R.

AU - Naka, Shuhei

AU - Okawa, R.

AU - Ooshima, T.

AU - Nakano, K.

PY - 2014

Y1 - 2014

N2 - Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.

AB - Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.

KW - Bacteraemia

KW - Inflammatory bowel diseases

KW - Interferon-gamma

KW - Liver

KW - Oral streptococci

UR - http://www.scopus.com/inward/record.url?scp=84897530070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897530070&partnerID=8YFLogxK

U2 - 10.1111/odi.12125

DO - 10.1111/odi.12125

M3 - Article

C2 - 23679203

AN - SCOPUS:84897530070

VL - 20

SP - 359

EP - 366

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 4

ER -