TY - JOUR
T1 - Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain
AU - Asanuma, Masato
AU - Miyazaki, Ikuko
AU - Higashi, Youichirou
AU - Tanaka, Ken Ichi
AU - Haque, Md Emdadul
AU - Fujita, Naoko
AU - Ogawa, Norio
PY - 2002/7/12
Y1 - 2002/7/12
N2 - The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.
AB - The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.
KW - 6-Hydroxydopamine
KW - Dopamine
KW - Dopamine transporter
KW - Knock-out mouse
KW - Metallothionein
KW - Reactive oxygen species
KW - Tyrosine hydroxylase
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U2 - 10.1016/S0304-3940(02)00346-4
DO - 10.1016/S0304-3940(02)00346-4
M3 - Article
C2 - 12098501
AN - SCOPUS:0037067511
VL - 327
SP - 61
EP - 65
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -