Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Ken Ichi Tanaka, Md Emdadul Haque, Naoko Fujita, Norio Ogawa

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalNeuroscience Letters
Volume327
Issue number1
DOIs
Publication statusPublished - Jul 12 2002

Keywords

  • 6-Hydroxydopamine
  • Dopamine
  • Dopamine transporter
  • Knock-out mouse
  • Metallothionein
  • Reactive oxygen species
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

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