Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain

Masato Asanuma; Ikuko Miyazaki; Youichirou Higashi; Ken Ichi Tanaka; Md Emdadul Haque; Naoko Fujita; Norio Ogawa

doi:10.1016/S0304-3940(02)00346-4

Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Ken Ichi Tanaka, Md Emdadul Haque, Naoko Fujita, Norio Ogawa

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Neuroscience Letters
Volume	327
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00346-4
Publication status	Published - Jul 12 2002

Keywords

6-Hydroxydopamine
Dopamine
Dopamine transporter
Knock-out mouse
Metallothionein
Reactive oxygen species
Tyrosine hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

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title = "Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain",

abstract = "The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.",

keywords = "6-Hydroxydopamine, Dopamine, Dopamine transporter, Knock-out mouse, Metallothionein, Reactive oxygen species, Tyrosine hydroxylase",

author = "Masato Asanuma and Ikuko Miyazaki and Youichirou Higashi and Tanaka, {Ken Ichi} and Haque, {Md Emdadul} and Naoko Fujita and Norio Ogawa",

year = "2002",

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T1 - Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain

AU - Asanuma, Masato

AU - Miyazaki, Ikuko

AU - Higashi, Youichirou

AU - Tanaka, Ken Ichi

AU - Haque, Md Emdadul

AU - Fujita, Naoko

AU - Ogawa, Norio

PY - 2002/7/12

Y1 - 2002/7/12

N2 - The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.

AB - The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals.

KW - 6-Hydroxydopamine

KW - Dopamine

KW - Dopamine transporter

KW - Knock-out mouse

KW - Metallothionein

KW - Reactive oxygen species

KW - Tyrosine hydroxylase

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