Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans

Qi Fu, Satoshi Iwase, Yuki Niimi, Atsunori Kamiya, Daisaku Michikami, Tadaaki Mano, Akio Suzumura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To test the hypothesis that leg vein filling and emptying functions could be impaired with advancing age, which would produce less blood volume redistribution toward the lower body and smaller sympathetic reflex response during mild gravitational stress, 9 young and 10 elderly healthy males were exposed to a lower body negative pressure (LBNP) of 15 mmHg. Venous occlusion plethysmography was used to determine the functions of the leg veins. We found that the baseline venous distensibility index (VDI) was lower (0.057±0.004 vs. 0.048± 0.003 ml·100 ml-1·mmHg-1, young vs. elderly; p<0.05), and half-emptying time (T1/2) was shorter (1.6±0.1 vs. 1.3±0.1 s, young vs. elderly; p<0.05) in the elderly. At 15 mmHg-LBNP, VDI was decreased and T1/2 was shortened significantly in the vounq qroup, but only slightly in the elderly group. Neither blood pressure nor heart rate changed significantly in either group. The reduction in peripheral venous pressure, which was recorded from the left antecubital vein at the cubital fossa, was less in the elderly, indicating a smaller decrease in central blood volume during LBNP; however, the enhancement of muscle sympathetic nerve activity was nearly the same as that in the young. We conclude that leg vein filling and emptying functions are impaired in elderly people, producing less blood pooling in the legs and smaller reduction in peripheral venous pressure during LBNP; the maintained sympathetic reflex response might be attributable to the well-preserved baroreflex function control of sympathetic outflow to the muscle in the elderly.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalJapanese Journal of Physiology
Volume52
Issue number1
DOIs
Publication statusPublished - May 11 2002
Externally publishedYes

Fingerprint

Lower Body Negative Pressure
Blood Volume
Reflex
Veins
Leg
Venous Pressure
Muscles
Plethysmography
Baroreflex
Heart Rate
Blood Pressure

Keywords

  • Gravitational stress
  • Half-emptying time
  • Muscle sympathetic nerve activity
  • Venous distensibility index

ASJC Scopus subject areas

  • Physiology

Cite this

Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans. / Fu, Qi; Iwase, Satoshi; Niimi, Yuki; Kamiya, Atsunori; Michikami, Daisaku; Mano, Tadaaki; Suzumura, Akio.

In: Japanese Journal of Physiology, Vol. 52, No. 1, 11.05.2002, p. 77-84.

Research output: Contribution to journalArticle

Fu, Qi ; Iwase, Satoshi ; Niimi, Yuki ; Kamiya, Atsunori ; Michikami, Daisaku ; Mano, Tadaaki ; Suzumura, Akio. / Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans. In: Japanese Journal of Physiology. 2002 ; Vol. 52, No. 1. pp. 77-84.
@article{fed26bc1ce744c89a2e25d14078d5a24,
title = "Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans",
abstract = "To test the hypothesis that leg vein filling and emptying functions could be impaired with advancing age, which would produce less blood volume redistribution toward the lower body and smaller sympathetic reflex response during mild gravitational stress, 9 young and 10 elderly healthy males were exposed to a lower body negative pressure (LBNP) of 15 mmHg. Venous occlusion plethysmography was used to determine the functions of the leg veins. We found that the baseline venous distensibility index (VDI) was lower (0.057±0.004 vs. 0.048± 0.003 ml·100 ml-1·mmHg-1, young vs. elderly; p<0.05), and half-emptying time (T1/2) was shorter (1.6±0.1 vs. 1.3±0.1 s, young vs. elderly; p<0.05) in the elderly. At 15 mmHg-LBNP, VDI was decreased and T1/2 was shortened significantly in the vounq qroup, but only slightly in the elderly group. Neither blood pressure nor heart rate changed significantly in either group. The reduction in peripheral venous pressure, which was recorded from the left antecubital vein at the cubital fossa, was less in the elderly, indicating a smaller decrease in central blood volume during LBNP; however, the enhancement of muscle sympathetic nerve activity was nearly the same as that in the young. We conclude that leg vein filling and emptying functions are impaired in elderly people, producing less blood pooling in the legs and smaller reduction in peripheral venous pressure during LBNP; the maintained sympathetic reflex response might be attributable to the well-preserved baroreflex function control of sympathetic outflow to the muscle in the elderly.",
keywords = "Gravitational stress, Half-emptying time, Muscle sympathetic nerve activity, Venous distensibility index",
author = "Qi Fu and Satoshi Iwase and Yuki Niimi and Atsunori Kamiya and Daisaku Michikami and Tadaaki Mano and Akio Suzumura",
year = "2002",
month = "5",
day = "11",
doi = "10.2170/jjphysiol.52.77",
language = "English",
volume = "52",
pages = "77--84",
journal = "Journal of Physiological Sciences",
issn = "1880-6546",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans

AU - Fu, Qi

AU - Iwase, Satoshi

AU - Niimi, Yuki

AU - Kamiya, Atsunori

AU - Michikami, Daisaku

AU - Mano, Tadaaki

AU - Suzumura, Akio

PY - 2002/5/11

Y1 - 2002/5/11

N2 - To test the hypothesis that leg vein filling and emptying functions could be impaired with advancing age, which would produce less blood volume redistribution toward the lower body and smaller sympathetic reflex response during mild gravitational stress, 9 young and 10 elderly healthy males were exposed to a lower body negative pressure (LBNP) of 15 mmHg. Venous occlusion plethysmography was used to determine the functions of the leg veins. We found that the baseline venous distensibility index (VDI) was lower (0.057±0.004 vs. 0.048± 0.003 ml·100 ml-1·mmHg-1, young vs. elderly; p<0.05), and half-emptying time (T1/2) was shorter (1.6±0.1 vs. 1.3±0.1 s, young vs. elderly; p<0.05) in the elderly. At 15 mmHg-LBNP, VDI was decreased and T1/2 was shortened significantly in the vounq qroup, but only slightly in the elderly group. Neither blood pressure nor heart rate changed significantly in either group. The reduction in peripheral venous pressure, which was recorded from the left antecubital vein at the cubital fossa, was less in the elderly, indicating a smaller decrease in central blood volume during LBNP; however, the enhancement of muscle sympathetic nerve activity was nearly the same as that in the young. We conclude that leg vein filling and emptying functions are impaired in elderly people, producing less blood pooling in the legs and smaller reduction in peripheral venous pressure during LBNP; the maintained sympathetic reflex response might be attributable to the well-preserved baroreflex function control of sympathetic outflow to the muscle in the elderly.

AB - To test the hypothesis that leg vein filling and emptying functions could be impaired with advancing age, which would produce less blood volume redistribution toward the lower body and smaller sympathetic reflex response during mild gravitational stress, 9 young and 10 elderly healthy males were exposed to a lower body negative pressure (LBNP) of 15 mmHg. Venous occlusion plethysmography was used to determine the functions of the leg veins. We found that the baseline venous distensibility index (VDI) was lower (0.057±0.004 vs. 0.048± 0.003 ml·100 ml-1·mmHg-1, young vs. elderly; p<0.05), and half-emptying time (T1/2) was shorter (1.6±0.1 vs. 1.3±0.1 s, young vs. elderly; p<0.05) in the elderly. At 15 mmHg-LBNP, VDI was decreased and T1/2 was shortened significantly in the vounq qroup, but only slightly in the elderly group. Neither blood pressure nor heart rate changed significantly in either group. The reduction in peripheral venous pressure, which was recorded from the left antecubital vein at the cubital fossa, was less in the elderly, indicating a smaller decrease in central blood volume during LBNP; however, the enhancement of muscle sympathetic nerve activity was nearly the same as that in the young. We conclude that leg vein filling and emptying functions are impaired in elderly people, producing less blood pooling in the legs and smaller reduction in peripheral venous pressure during LBNP; the maintained sympathetic reflex response might be attributable to the well-preserved baroreflex function control of sympathetic outflow to the muscle in the elderly.

KW - Gravitational stress

KW - Half-emptying time

KW - Muscle sympathetic nerve activity

KW - Venous distensibility index

UR - http://www.scopus.com/inward/record.url?scp=0036235898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036235898&partnerID=8YFLogxK

U2 - 10.2170/jjphysiol.52.77

DO - 10.2170/jjphysiol.52.77

M3 - Article

C2 - 12047805

AN - SCOPUS:0036235898

VL - 52

SP - 77

EP - 84

JO - Journal of Physiological Sciences

JF - Journal of Physiological Sciences

SN - 1880-6546

IS - 1

ER -