Age-related histopathologic changes in the human cochlea: A temporal bone study

Takeshi Kusunoki, Sebahattin Cureoglu, Patricia A. Schachern, Kazuyasu Baba, Shin Kariya, Michael M. Paparella

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Previous reports on aging of human cochlea included subjects with ear diseases or ototoxic drugs. We studied spiral ganglion cells, hair cells, and lateral wall of cochlea from subjects without ear disease or ototoxic drugs. This study included 39 temporal bones from 24 subjects aged 1 day to 86 years. We assessed standard cytocochleograms, mean loss of fibrocytes in spiral ligament, and areas of stria vascularis. Losses of outer hair cells and fibrocytes were significantly greater in childern, adults, and the elderly compared with infants. Spiral ganglion cell loss was significantly greater in adults and elderly compared with infants and children. Areas of stria vascularis of infants were significantly larger than the elderly. Degenerative changes of outer hair cells occur in children but spiral ganglion cells remain the same until around 20 years. Degeneration of stria vascularis due to aging appears to be slower than spiral ligament. EBM rating: C.

Original languageEnglish
Pages (from-to)897-903
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume131
Issue number6
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

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Stria Vascularis
Spiral Ganglion
Outer Auditory Hair Cells
Temporal Bone
Cochlea
Spiral Ligament of Cochlea
Ear Diseases
Pharmaceutical Preparations
Cell Wall

ASJC Scopus subject areas

  • Otorhinolaryngology

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Age-related histopathologic changes in the human cochlea : A temporal bone study. / Kusunoki, Takeshi; Cureoglu, Sebahattin; Schachern, Patricia A.; Baba, Kazuyasu; Kariya, Shin; Paparella, Michael M.

In: Otolaryngology - Head and Neck Surgery, Vol. 131, No. 6, 12.2004, p. 897-903.

Research output: Contribution to journalArticle

Kusunoki, Takeshi ; Cureoglu, Sebahattin ; Schachern, Patricia A. ; Baba, Kazuyasu ; Kariya, Shin ; Paparella, Michael M. / Age-related histopathologic changes in the human cochlea : A temporal bone study. In: Otolaryngology - Head and Neck Surgery. 2004 ; Vol. 131, No. 6. pp. 897-903.
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