Abstract
Age-related Epstein-Barr virus-associated IB-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV- associated large B-cell lymphoma in the elderly without predisposing immunodeficiency. In nearly one-third of cases, aEBV- LPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphologic similarity to classic Hodgkin lymphoma (cHL). The aim of this study was to clarify clinicopathologic differences between the polymorphic subtype of aEBVLPD (n = 34) and EBV + cHL (n = 108) in patients aged 50 years or older. Results showed that aEBVLPD was more closely associated with aggressive clinical parameters than cHL, with a higher age at onset (71 vs 63 years); lower male predominance (male-female ratio, 1.4 vs 3.3); and a higher rate of involvement of the skin (18% vs 2%), gastrointestinal tract (15% vs 4%), and lung (12% vs 2%). aEBVLPD was histopathologically characterized by a higher ratio of geographic necrosis, greater increase (> 30%) in cytotoxic T cells among background lymphocytes, higher positivity for CD20 and EBNA2, and absence of CD15 expression. As predicted by the clinical profile, aEBV-LPD had a significantly poorer prognosis than EBV+ cHL (P <.001). The polymorphous subtype of a EBVLPD constitutes an aggressive group with an immune response distinct from EBV+ cHL, and requires the development of innovative therapeutic strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 2629-2636 |
| Number of pages | 8 |
| Journal | Blood |
| Volume | 113 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Mar 19 2009 |
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ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology
Cite this
Age-related epstein-barr virus (EBV) associated B-cell lymphoproliferative disorders : Comparison with EBV-positive classic hodgkin lymphoma in elderly patients. / Asano, Naoko; Yamamoto, Kazuhito; Tamaru, Jun Ichi; Oyama, Takashi; Ishida, Fumihiro; Ohshima, Koichi; Yoshino, Tadashi; Nakamura, Naoya; Mori, Shigeo; Yoshie, Osamu; Shimoyama, Yoshie; Morishima, Yasuo; Kinoshita, Tomohiro; Nakamura, Shigeo.
In: Blood, Vol. 113, No. 12, 19.03.2009, p. 2629-2636.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related epstein-barr virus (EBV) associated B-cell lymphoproliferative disorders
T2 - Comparison with EBV-positive classic hodgkin lymphoma in elderly patients
AU - Asano, Naoko
AU - Yamamoto, Kazuhito
AU - Tamaru, Jun Ichi
AU - Oyama, Takashi
AU - Ishida, Fumihiro
AU - Ohshima, Koichi
AU - Yoshino, Tadashi
AU - Nakamura, Naoya
AU - Mori, Shigeo
AU - Yoshie, Osamu
AU - Shimoyama, Yoshie
AU - Morishima, Yasuo
AU - Kinoshita, Tomohiro
AU - Nakamura, Shigeo
PY - 2009/3/19
Y1 - 2009/3/19
N2 - Age-related Epstein-Barr virus-associated IB-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV- associated large B-cell lymphoma in the elderly without predisposing immunodeficiency. In nearly one-third of cases, aEBV- LPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphologic similarity to classic Hodgkin lymphoma (cHL). The aim of this study was to clarify clinicopathologic differences between the polymorphic subtype of aEBVLPD (n = 34) and EBV + cHL (n = 108) in patients aged 50 years or older. Results showed that aEBVLPD was more closely associated with aggressive clinical parameters than cHL, with a higher age at onset (71 vs 63 years); lower male predominance (male-female ratio, 1.4 vs 3.3); and a higher rate of involvement of the skin (18% vs 2%), gastrointestinal tract (15% vs 4%), and lung (12% vs 2%). aEBVLPD was histopathologically characterized by a higher ratio of geographic necrosis, greater increase (> 30%) in cytotoxic T cells among background lymphocytes, higher positivity for CD20 and EBNA2, and absence of CD15 expression. As predicted by the clinical profile, aEBV-LPD had a significantly poorer prognosis than EBV+ cHL (P <.001). The polymorphous subtype of a EBVLPD constitutes an aggressive group with an immune response distinct from EBV+ cHL, and requires the development of innovative therapeutic strategies.
AB - Age-related Epstein-Barr virus-associated IB-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV- associated large B-cell lymphoma in the elderly without predisposing immunodeficiency. In nearly one-third of cases, aEBV- LPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphologic similarity to classic Hodgkin lymphoma (cHL). The aim of this study was to clarify clinicopathologic differences between the polymorphic subtype of aEBVLPD (n = 34) and EBV + cHL (n = 108) in patients aged 50 years or older. Results showed that aEBVLPD was more closely associated with aggressive clinical parameters than cHL, with a higher age at onset (71 vs 63 years); lower male predominance (male-female ratio, 1.4 vs 3.3); and a higher rate of involvement of the skin (18% vs 2%), gastrointestinal tract (15% vs 4%), and lung (12% vs 2%). aEBVLPD was histopathologically characterized by a higher ratio of geographic necrosis, greater increase (> 30%) in cytotoxic T cells among background lymphocytes, higher positivity for CD20 and EBNA2, and absence of CD15 expression. As predicted by the clinical profile, aEBV-LPD had a significantly poorer prognosis than EBV+ cHL (P <.001). The polymorphous subtype of a EBVLPD constitutes an aggressive group with an immune response distinct from EBV+ cHL, and requires the development of innovative therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=63849290800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849290800&partnerID=8YFLogxK
U2 - 10.1182/blood-2008-06-164806
DO - 10.1182/blood-2008-06-164806
M3 - Article
C2 - 19075188
AN - SCOPUS:63849290800
VL - 113
SP - 2629
EP - 2636
JO - Blood
JF - Blood
SN - 0006-4971
IS - 12
ER -