Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

N. Yamaga, H. Kawasaki, K. Inaizumi, M. Shimizu, A. Nakamura, Y. Kurosaki

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Abstract

Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalJapanese Journal of Pharmacology
Volume86
Issue number4
DOIs
Publication statusPublished - Oct 3 2001

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Keywords

  • Calcitonin gene-related peptide (CGRP) mRNA
  • Mesenteric arterial CGRP content
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Pharmacology

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