Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

N. Yamaga, H. Kawasaki, K. Inaizumi, M. Shimizu, A. Nakamura, Yuji Kurosaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalJapanese Journal of Pharmacology
Volume86
Issue number4
DOIs
Publication statusPublished - 2001

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Calcitonin Gene-Related Peptide
Spinal Ganglia
Inbred SHR Rats
Messenger RNA
Inbred WKY Rats
Mesenteric Arteries
Spinal Cord

Keywords

  • Calcitonin gene-related peptide (CGRP) mRNA
  • Mesenteric arterial CGRP content
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats. / Yamaga, N.; Kawasaki, H.; Inaizumi, K.; Shimizu, M.; Nakamura, A.; Kurosaki, Yuji.

In: Japanese Journal of Pharmacology, Vol. 86, No. 4, 2001, p. 448-450.

Research output: Contribution to journalArticle

Yamaga, N. ; Kawasaki, H. ; Inaizumi, K. ; Shimizu, M. ; Nakamura, A. ; Kurosaki, Yuji. / Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats. In: Japanese Journal of Pharmacology. 2001 ; Vol. 86, No. 4. pp. 448-450.
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AU - Nakamura, A.

AU - Kurosaki, Yuji

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