Age-related changes ofurinary nitrite/nitrate excretion in normal children

Hirokazu Tsukahara, Masahiro Hiraoka, Chikahide Hori, Takeshi Miyanomae, Kiyoshi Kikuchi, Masakatsu Sudo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We measured the urinary excretion of nitrite/nitrate, stable metabolites of nitric oxide, using the brucine method in 90 healthy normal children (47 boys and 43 girls), aged from 1.0 to 17.1 years, to establish the age-related normal range in children. The urinary nitrite/nitrate excretion was highest in the youngest children and decreased in an age-dependent manner to reach constant levels at about 12 years of agein both sexes. The data may be useful in identifying sick children with abnormal nitric oxide production.

Original languageEnglish
Pages (from-to)307-309
Number of pages3
Issue number3
Publication statusPublished - 1997
Externally publishedYes


  • Age
  • Nitric oxide
  • Normal children
  • Urinary nitrite/nitrate

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology


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