TY - JOUR
T1 - Age-related changes of IgE-mediated allergic reaction in patients with late onset asthma - Relationship between IgE-mediated allergy and age at onset
AU - Yokota, S.
AU - Mitsunobu, F.
AU - Mifune, T.
AU - Hosaki, Y.
AU - Ashida, K.
AU - Tsugeno, H.
AU - Tanizaki, Y.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - We examined age-related changes in the IgE-mediated allergic reaction in patients with late-onset asthma, whose asthma first occurred at over 40 years. (1)The number of patients with a high serum IgE level (over 300IU/ml) was larger in patients with an age of onset between 40 and 49 (40~49 years group) and in patients older than 60 at age of onset (60~year group) than in patients with an age of onset between 50 and 59 (50~59 year group). (2)A positive RAST score to house dust mite (HDm) allergen was more frequently found in the 40~49 year group and in the 60~ year group than in the 50 ~59 year group. Frequency of positive RAST score to HDm in the 50~59 year group was significantly lower (p<0.01) than in early-onset asthma patients (age at onset less than 39 years). (3)Frequency of family history of asthma in the 50~59 years group was high, being equal to that of early-onset asthma patients. (4)In the 50~59 year group, the frequency of severe asthma was comparatively higher than that of the other groups. The frequency of IgE- mediated allergic reaction changed in regard to age of onset of asthma, and allergic reactions in late-onset asthma partially resembled those of earlyonset asthma. These results suggest that an atopic constitution is related to the onset of bronchial asthma in the elderly.
AB - We examined age-related changes in the IgE-mediated allergic reaction in patients with late-onset asthma, whose asthma first occurred at over 40 years. (1)The number of patients with a high serum IgE level (over 300IU/ml) was larger in patients with an age of onset between 40 and 49 (40~49 years group) and in patients older than 60 at age of onset (60~year group) than in patients with an age of onset between 50 and 59 (50~59 year group). (2)A positive RAST score to house dust mite (HDm) allergen was more frequently found in the 40~49 year group and in the 60~ year group than in the 50 ~59 year group. Frequency of positive RAST score to HDm in the 50~59 year group was significantly lower (p<0.01) than in early-onset asthma patients (age at onset less than 39 years). (3)Frequency of family history of asthma in the 50~59 years group was high, being equal to that of early-onset asthma patients. (4)In the 50~59 year group, the frequency of severe asthma was comparatively higher than that of the other groups. The frequency of IgE- mediated allergic reaction changed in regard to age of onset of asthma, and allergic reactions in late-onset asthma partially resembled those of earlyonset asthma. These results suggest that an atopic constitution is related to the onset of bronchial asthma in the elderly.
KW - Aging at asthma onset
KW - Family history of atopy
KW - Inhalant allergen of RAST
KW - Late onset asthma
KW - Serum IgE level
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U2 - 10.3143/geriatrics.35.367
DO - 10.3143/geriatrics.35.367
M3 - Article
C2 - 9711091
AN - SCOPUS:0031809527
VL - 35
SP - 367
EP - 373
JO - Japanese Journal of Geriatrics
JF - Japanese Journal of Geriatrics
SN - 0300-9173
IS - 5
ER -