TY - JOUR
T1 - Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice
AU - Ilieva, Hristelina S.
AU - Nagano, Isao
AU - Murakami, Tetsuro
AU - Shiote, Mito
AU - Manabe, Yasuhiro
AU - Abe, Koji
PY - 2003/6
Y1 - 2003/6
N2 - Peroxisomal membrane protein 70 (PMP70) and Cu/Zn superoxide dismutase (SOD1) were examined in the spinal cords of transgenic (Tg) mice expressing a human mutant SOD1 protein (G93A) and their age-matched controls at 8, 20 and 32 weeks by immunohistochemistry. At pre-symptomatic 20 weeks and symptomatic 32 weeks, PMP70 was reduced in the cytoplasm of motor neurons in Tg animals and increased in glial cells in anterior horn at late age. SOD1 showed a progressive increase of dot-like deposits in the neuropil of anterior horn of Tg mice, and a late decrease of signal intensity in the white matter and motor neurons at 32 weeks. It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model.
AB - Peroxisomal membrane protein 70 (PMP70) and Cu/Zn superoxide dismutase (SOD1) were examined in the spinal cords of transgenic (Tg) mice expressing a human mutant SOD1 protein (G93A) and their age-matched controls at 8, 20 and 32 weeks by immunohistochemistry. At pre-symptomatic 20 weeks and symptomatic 32 weeks, PMP70 was reduced in the cytoplasm of motor neurons in Tg animals and increased in glial cells in anterior horn at late age. SOD1 showed a progressive increase of dot-like deposits in the neuropil of anterior horn of Tg mice, and a late decrease of signal intensity in the white matter and motor neurons at 32 weeks. It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model.
KW - Amyotrophic lateral sclerosis
KW - Cu/Zn superoxide dismutase
KW - Peroxisome
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UR - http://www.scopus.com/inward/citedby.url?scp=0038692029&partnerID=8YFLogxK
U2 - 10.1179/016164103101201607
DO - 10.1179/016164103101201607
M3 - Article
C2 - 12870272
AN - SCOPUS:0038692029
VL - 25
SP - 423
EP - 426
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 4
ER -