Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice

Results from Japanese observational cohort

Teruo Inamoto, Haruhito Azuma, Shiro Hinotsu, Taiji Tsukamoto, Mototsugu Oya, Osamu Ogawa, Tadaichi Kitamura, Suzuki Kazuhiro, Seiji Naito, Mikio Namiki, Kazuo Nishimura, Yoshihiko Hirao, Michiyuki Usami, Masaru Murai, Hideyuki Akaza

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Primary androgen deprivation therapy (PADT) had been used extensively in Japan than in the USA and European countries regardless of the disease risk or patient's age. To illustrate the consequence of PADT from daily clinical practice, we evaluated the relationship among age, disease risk, and survival of patients with prostate cancer treated by PADT in largest Asian cohort. Patients and methods: The 19,246 men subjected to PADT enrolled in the Japan Study Group of Prostate Cancer were enrolled for the present analysis. Patients were divided into four groups based on age at diagnosis: age 75. Risk was stratified according to the Japan Cancer of the Prostate Risk Assessment (J-CAPRA). Multivariate competing risks regression analysis was performed for OS and PFS. Results: There was downward stage migration over age. Among men aged >75 years, 34.1 % had nodal or distant metastatic disease. In contrast, 56.0 % of patients aged

Original languageEnglish
Pages (from-to)1197-1204
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume140
Issue number7
DOIs
Publication statusPublished - 2014

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Androgens
Prostatic Neoplasms
Survival
Japan
Therapeutics
Regression Analysis

Keywords

  • ADT
  • Age at diagnosis
  • CaP

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice : Results from Japanese observational cohort. / Inamoto, Teruo; Azuma, Haruhito; Hinotsu, Shiro; Tsukamoto, Taiji; Oya, Mototsugu; Ogawa, Osamu; Kitamura, Tadaichi; Kazuhiro, Suzuki; Naito, Seiji; Namiki, Mikio; Nishimura, Kazuo; Hirao, Yoshihiko; Usami, Michiyuki; Murai, Masaru; Akaza, Hideyuki.

In: Journal of Cancer Research and Clinical Oncology, Vol. 140, No. 7, 2014, p. 1197-1204.

Research output: Contribution to journalArticle

Inamoto, T, Azuma, H, Hinotsu, S, Tsukamoto, T, Oya, M, Ogawa, O, Kitamura, T, Kazuhiro, S, Naito, S, Namiki, M, Nishimura, K, Hirao, Y, Usami, M, Murai, M & Akaza, H 2014, 'Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice: Results from Japanese observational cohort', Journal of Cancer Research and Clinical Oncology, vol. 140, no. 7, pp. 1197-1204. https://doi.org/10.1007/s00432-014-1638-y
Inamoto, Teruo ; Azuma, Haruhito ; Hinotsu, Shiro ; Tsukamoto, Taiji ; Oya, Mototsugu ; Ogawa, Osamu ; Kitamura, Tadaichi ; Kazuhiro, Suzuki ; Naito, Seiji ; Namiki, Mikio ; Nishimura, Kazuo ; Hirao, Yoshihiko ; Usami, Michiyuki ; Murai, Masaru ; Akaza, Hideyuki. / Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice : Results from Japanese observational cohort. In: Journal of Cancer Research and Clinical Oncology. 2014 ; Vol. 140, No. 7. pp. 1197-1204.
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AU - Tsukamoto, Taiji

AU - Oya, Mototsugu

AU - Ogawa, Osamu

AU - Kitamura, Tadaichi

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AU - Naito, Seiji

AU - Namiki, Mikio

AU - Nishimura, Kazuo

AU - Hirao, Yoshihiko

AU - Usami, Michiyuki

AU - Murai, Masaru

AU - Akaza, Hideyuki

PY - 2014

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