Age- and division-of-labour-dependent differential expression of a novel non-coding RNA, Nb-1, in the brain of worker honeybees, Apis mellifera L.

H. Tadano, Y. Yamazaki, H. Takeuchi, T. Kubo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To elucidate the molecular mechanisms underlying honeybee social behaviours, we identified a novel gene, Nb-1, whose expression in the worker brain changes according to the age-dependent division of labour in normal colonies. The open reading frames contained in the Nb-1 cDNA were not conserved in the homologue of a related species, suggesting that the Nb-1 gene product is a non-coding RNA. The distribution of Nb-1-expressing cells partially overlapped that of octopamine-immunoreactive cells and neurosecretory cells, the latter of which are involved in the synthesis and secretion of juvenile hormone (JH). Octopamine and JH control worker task transition, and thus Nb-1 might be involved in task transition through the modulation of octopamine/JH synthesis and secretion.

Original languageEnglish
Pages (from-to)715-726
Number of pages12
JournalInsect Molecular Biology
Volume18
Issue number6
DOIs
Publication statusPublished - Dec 1 2009
Externally publishedYes

Keywords

  • Apis mellifera
  • Division of labour
  • Neurosecretory cell
  • Non-coding RNA
  • Octopamine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science

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