TY - JOUR
T1 - Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus
AU - Sumita, Y.
AU - Fukasawa, M.
AU - Okuda, T.
PY - 1990
Y1 - 1990
N2 - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
AB - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
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U2 - 10.1128/AAC.34.3.484
DO - 10.1128/AAC.34.3.484
M3 - Article
C2 - 2334163
AN - SCOPUS:0025189681
VL - 34
SP - 484
EP - 486
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
ER -