Abstract
SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
| Original language | English |
|---|---|
| Pages (from-to) | 484-486 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus. / Sumita, Yoshihiro; Fukasawa, M.; Okuda, T.
In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 3, 01.01.1990, p. 484-486.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus
AU - Sumita, Yoshihiro
AU - Fukasawa, M.
AU - Okuda, T.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
AB - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
UR - http://www.scopus.com/inward/record.url?scp=0025189681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025189681&partnerID=8YFLogxK
U2 - 10.1128/AAC.34.3.484
DO - 10.1128/AAC.34.3.484
M3 - Article
C2 - 2334163
AN - SCOPUS:0025189681
VL - 34
SP - 484
EP - 486
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
ER -