Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus

Y. Sumita; M. Fukasawa; T. Okuda

doi:10.1128/AAC.34.3.484

Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus

Y. Sumita, M. Fukasawa, T. Okuda

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [¹⁴C]benzylpenicillin was used. However, binding of [¹⁴C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

Original language	English
Pages (from-to)	484-486
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	34
Issue number	3
DOIs	https://doi.org/10.1128/AAC.34.3.484
Publication status	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.34.3.484

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abstract = "SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.",

author = "Y. Sumita and M. Fukasawa and T. Okuda",

year = "1990",

doi = "10.1128/AAC.34.3.484",

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T1 - Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus

AU - Sumita, Y.

AU - Fukasawa, M.

AU - Okuda, T.

PY - 1990

Y1 - 1990

N2 - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

AB - SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

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JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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ER -

Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus

Abstract

ASJC Scopus subject areas

UN SDGs

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