Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus

Y. Sumita, M. Fukasawa, T. Okuda

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number3
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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