Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity

Michael Lahn, Arihiko Kanehiro, Youn Soo Hahn, J. M. Wands, M. Kemal Aydintug, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

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11 Citations (Scopus)

Abstract

Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specifically abrogated both effector and regulatory functions of the targeted T cells. Specific mAbs targeting αβ T cells suppressed and those targeting γδ T cells enhanced AHR. Moreover, specific mAbs directed against subsets of γδ T cells varied in their effect on AHR. Using this approach of targeting either αβ or γδ T cells reduced airway eosinophila, although the effect of mAbs specific for αβ T cells was stronger. The use of aerosolized anti-TCR mAbs may offer an effective approach for the treatment of airway inflammation and AHR.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume134
Issue number1
DOIs
Publication statusPublished - Jun 10 2004

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Keywords

  • Aerosolized monoclonal antibodies
  • Airway hyperreactivity
  • Inflammation, airways
  • Ovalbumin
  • T cell receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lahn, M., Kanehiro, A., Hahn, Y. S., Wands, J. M., Aydintug, M. K., O'Brien, R. L., Gelfand, E. W., & Born, W. K. (2004). Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity. International Archives of Allergy and Immunology, 134(1), 49-55. https://doi.org/10.1159/000077533