Advantages of salvage photodynamic therapy using talaporfin sodium for local failure after chemoradiotherapy or radiotherapy for esophageal cancer

Tatsunori Minamide, Yusuke Yoda, Keisuke Hori, Kensuke Shinmura, Yasuhiro Oono, Hiroaki Ikematsu, Tomonori Yano

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Photodynamic therapy (PDT) is a salvage treatment for local failure following chemoradiotherapy (CRT) for esophageal cancer. This study aimed to evaluate the efficacy and safety of salvage PDT using the second-generation photosensitizer, talaporfin sodium (L-PDT), and compare L-PDT to PDT using porfimer sodium (P-PDT). Methods: We retrospectively analyzed clinical outcomes of patients treated with L-PDT and P-PDT. Patients with histologically proven local failure limited to the shallow muscularis propria layer (T2) after CRT or radiotherapy (RT) for esophageal cancer were enrolled. Results: A total of 121 patients were enrolled in this study. L-PDT and P-PDT groups consisted of 44 and 77 patients, respectively. The overall local complete response (L-CR) rate was 62.1% (95% confidence interval [CI], 52.6–70.9), and the L-PDT group showed a better L-CR rate than did the P-PDT group (69.0% [95% CI 52.9–82.4] vs. 58.1% [95% CI 46.1–69.5]). The common complications of skin phototoxicity, esophageal stricture, and esophageal fistula were all less frequent in the L-PDT group than in the P-PDT group. The only treatment-related death in this study was in the P-PDT group. With a median follow-up period of 15.8 months (interquartile range 7.1–37.4) in all 121 patients, overall survival rate at 1 year was significantly higher among patients who achieved L-CR (91.2% [95% CI 80.2–96.3]) than among those who could not achieve L-CR with PDT (50.8% [95% CI 33.6–65.6]). Conclusions: L-PDT represented better short-term outcomes than P-PDT as a salvage treatment for local failure following CRT or RT for esophageal cancer.

Original languageEnglish
Pages (from-to)899-906
Number of pages8
JournalSurgical Endoscopy
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 1 2020
Externally publishedYes

Keywords

  • Chemoradiotherapy
  • Esophageal cancer
  • Photodynamic therapy
  • Porfimer sodium
  • Talaporfin sodium

ASJC Scopus subject areas

  • Surgery

Fingerprint

Dive into the research topics of 'Advantages of salvage photodynamic therapy using talaporfin sodium for local failure after chemoradiotherapy or radiotherapy for esophageal cancer'. Together they form a unique fingerprint.

Cite this