Advances in the molecular biology of malignant mesothelioma

Shinichi Toyooka, Takumi Kishimoto, Hiroshi Date

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as a result of widespread exposure to asbestos. As for the molecular alterations that occur in MM, chromosome alterations including homo-deletion of the P16 and P14 genes located in the 9p21 are well known. Mutations are rare in the P53 and Ras genes, which are frequently present in epithelial solid tumors. However, mutations are frequently present in the neurofibromatosis type 2 gene. Epigenetic alterations including DNA methylation have been found in the MM, the profile of which is different from that of lung cancer, although differential diagnosis is sometimes clinically difficult. As in other malignant tumors, genes that are related to immortalization, proliferation, metastasis, angiogenesis, and anti-apoptosis are also overexpressed in MM, contributing to its malignant phenotype. It is of interest that simian virus 40 has been implicated to be one of the causative factors of MM in western countries. Although the causative role of asbestos is well-known in MM, much less information is available for MM than for other malignant tumors regarding the molecular alterations that occur in the disease. In terms of future tasks, it will be necessary to apply the knowledge that is learned about molecular alterations to clinical practice and to further elucidate the pathogenesis of MM with extensive research. Copyright

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Medica Okayama
Volume62
Issue number1
Publication statusPublished - Feb 2008

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Molecular biology
Tumors
Molecular Biology
Genes
Asbestos
Chromosomes
Viruses
Neoplasms
Neurofibromatosis 2 Genes
Apoptosis
Neurofibromatosis 2
p16 Genes
Malignant Mesothelioma
Mutation
Simian virus 40
ras Genes
p53 Genes
DNA Methylation
Epigenomics
Lung Neoplasms

Keywords

  • Malignant mesothelioma
  • Methylation
  • P16

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Advances in the molecular biology of malignant mesothelioma. / Toyooka, Shinichi; Kishimoto, Takumi; Date, Hiroshi.

In: Acta Medica Okayama, Vol. 62, No. 1, 02.2008, p. 1-7.

Research output: Contribution to journalArticle

Toyooka, S, Kishimoto, T & Date, H 2008, 'Advances in the molecular biology of malignant mesothelioma', Acta Medica Okayama, vol. 62, no. 1, pp. 1-7.
Toyooka, Shinichi ; Kishimoto, Takumi ; Date, Hiroshi. / Advances in the molecular biology of malignant mesothelioma. In: Acta Medica Okayama. 2008 ; Vol. 62, No. 1. pp. 1-7.
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