TY - JOUR
T1 - Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy
T2 - Report of a case
AU - Sadamori, Hiroshi
AU - Yagi, Takahito
AU - Shigeyasu, Kunitoshi
AU - Umeda, Yuzo
AU - Sugihara, Masahiro
AU - Yokomichi, Naosuke
AU - Ohara, Toshiaki
AU - Nishida, Naoshi
AU - Nagasaka, Takeshi
AU - Goel, Ajay
AU - Fujiwara, Toshiyoshi
PY - 2013/12/1
Y1 - 2013/12/1
N2 - We present a case in which combination chemotherapy was used to successfully treat hepatocellular carcinoma (HCC) with rapid progression of lymph node (LN) metastases after liver resection. In addition, epithelial to mesenchymal transition (EMT) markers were examined immunohistochemically. A 43-year-old man who had been diagnosed with HCC showed an enlarged LN near the hepatic artery proper. After extended left lobectomy with lymphadenectomy in the hepatoduodenal ligament, he experienced rapid progression of metastases to the para-aortic and mediastinal LN. Partial remission was achieved after induction and maintenance of combination chemotherapy using etoposide, carboplatin, epirubicin and 5-fluorouracil. As a consequence of this treatment, the patient survived 10months. Immunohistochemical studies demonstrated that HCC cells in the metastatic LN showed low expression of E-cadherin and high expression of N-cadherin and vimentin, indicating EMT. Combination chemotherapy may prove effective for patients with HCC accompanied by LN metastases that show features of EMT.
AB - We present a case in which combination chemotherapy was used to successfully treat hepatocellular carcinoma (HCC) with rapid progression of lymph node (LN) metastases after liver resection. In addition, epithelial to mesenchymal transition (EMT) markers were examined immunohistochemically. A 43-year-old man who had been diagnosed with HCC showed an enlarged LN near the hepatic artery proper. After extended left lobectomy with lymphadenectomy in the hepatoduodenal ligament, he experienced rapid progression of metastases to the para-aortic and mediastinal LN. Partial remission was achieved after induction and maintenance of combination chemotherapy using etoposide, carboplatin, epirubicin and 5-fluorouracil. As a consequence of this treatment, the patient survived 10months. Immunohistochemical studies demonstrated that HCC cells in the metastatic LN showed low expression of E-cadherin and high expression of N-cadherin and vimentin, indicating EMT. Combination chemotherapy may prove effective for patients with HCC accompanied by LN metastases that show features of EMT.
KW - Chemotherapy
KW - Epithelial to mesenchymal transition
KW - Hepatocellular carcinoma
KW - Liver resection
KW - Lymph node metastases
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U2 - 10.1111/hepr.12080
DO - 10.1111/hepr.12080
M3 - Article
AN - SCOPUS:84891006369
VL - 43
SP - 1368
EP - 1373
JO - Hepatology Research
JF - Hepatology Research
SN - 1386-6346
IS - 12
ER -