Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: Report of a case

Hiroshi Sadamori, Takahito Yagi, Kunitoshi Shigeyasu, Yuzo Umeda, Masahiro Sugihara, Naosuke Yokomichi, Toshiaki Ohara, Naoshi Nishida, Takeshi Nagasaka, Ajay Goel, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We present a case in which combination chemotherapy was used to successfully treat hepatocellular carcinoma (HCC) with rapid progression of lymph node (LN) metastases after liver resection. In addition, epithelial to mesenchymal transition (EMT) markers were examined immunohistochemically. A 43-year-old man who had been diagnosed with HCC showed an enlarged LN near the hepatic artery proper. After extended left lobectomy with lymphadenectomy in the hepatoduodenal ligament, he experienced rapid progression of metastases to the para-aortic and mediastinal LN. Partial remission was achieved after induction and maintenance of combination chemotherapy using etoposide, carboplatin, epirubicin and 5-fluorouracil. As a consequence of this treatment, the patient survived 10months. Immunohistochemical studies demonstrated that HCC cells in the metastatic LN showed low expression of E-cadherin and high expression of N-cadherin and vimentin, indicating EMT. Combination chemotherapy may prove effective for patients with HCC accompanied by LN metastases that show features of EMT.

Original languageEnglish
Pages (from-to)1368-1373
Number of pages6
JournalHepatology Research
Volume43
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Epithelial-Mesenchymal Transition
Hepatocellular Carcinoma
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
Combination Drug Therapy
Cadherins
Maintenance Chemotherapy
Epirubicin
Hepatic Artery
Carboplatin
Vimentin
Etoposide
Lymph Node Excision
Ligaments
Fluorouracil
Liver

Keywords

  • Chemotherapy
  • Epithelial to mesenchymal transition
  • Hepatocellular carcinoma
  • Liver resection
  • Lymph node metastases

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy : Report of a case. / Sadamori, Hiroshi; Yagi, Takahito; Shigeyasu, Kunitoshi; Umeda, Yuzo; Sugihara, Masahiro; Yokomichi, Naosuke; Ohara, Toshiaki; Nishida, Naoshi; Nagasaka, Takeshi; Goel, Ajay; Fujiwara, Toshiyoshi.

In: Hepatology Research, Vol. 43, No. 12, 12.2013, p. 1368-1373.

Research output: Contribution to journalArticle

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