Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction

Katsuhisa Ohashi, Hideo Kohka Takahashi, Shuji Mori, Keyue Liu, Hidenori Wake, Hiroshi Sadamori, Hiroaki Matsuda, Takahito Yagi, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Posttransplant diabetes mellitus (PTDM) is a frequent complication among transplant recipients. Ligation of advanced glycation end products (AGEs) with their receptor (RAGE) on monocytes/macrophages plays roles in the diabetes complications. The enhancement of adhesion molecule expression on monocytes/macrophages activates T-cells, leading to reduced allograft survival. We investigated the effect of four distinct AGE subtypes (AGE-2/AGE-3/AGE-4/AGE-5) on the expressions of intracellular adhesion molecule (ICAM)-1, B7.1, B7.2 and CD40 on monocytes, the production of interferon (IFN)-γ and tumor necrosis factor (TNF)-α and the proliferation of T-cells during human mixed lymphocyte reaction (MLR). AGE-2 and AGE-3 selectively induced the adhesion molecule expression, cytokine production and T-cell proliferation. The AGE-induced up-regulation of adhesion molecule expression was involved in the cytokine production and T-cell proliferation. AGE-2 and AGE-3 up-regulated the expression of RAGE on monocytes; therefore, the AGEs may activate monocytes, leading to the up-regulation of adhesion molecule expression, cytokine production and T-cell proliferation.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalClinical Immunology
Volume134
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Advanced glycation end products
  • Mixed lymphocyte reaction
  • Posttransplant diabetes mellitus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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