Adsorption of mutagens to chlorophyllin-chitosan, an insoluble form of chlorophyllin

Sakae Arimoto, Nanaho Harada, Risa Tokunaga, Jun Ichi Odo, Hikoya Hayatsu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Chlorophyllin, a water soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic actions of compounds having polycyclic structures, e.g. heterocyclic amines and aflatoxin B1. There is evidence that this suppressing effect arises, at least in part, by a complex formation between the porphyrin-like structure of chlorophyllin and the planar molecular surfaces of these compounds. We report here that chlorophyllin can form an insoluble salt-like material when mixed with chitosan, a polyglucosamine, and that the solid chlorophyllin-chitosan thus prepared can efficiently trap polycyclic mutagenic compounds. The adsorbed polycyclic mutagens were elutable with buffers of acidic pH, but only to small extents. Chlorophyllin-chitosan may be expected to be useful as an intercepting agent against polycyclic mutagens and carcinogens.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume381
Issue number2
DOIs
Publication statusPublished - Nov 28 1997

Fingerprint

Mutagens
Chitosan
Adsorption
Polycyclic Compounds
Aflatoxin B1
Porphyrins
Chlorophyll
Carcinogens
Amines
Buffers
Salts
chlorophyllin
Water

Keywords

  • Adsorption
  • Affinity separation
  • Aflatoxin B
  • Chitosan
  • Chlorophyllin
  • Heterocyclic amine
  • Polycyclic mutagen
  • Polyglacosamine
  • Trp-P-2

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Molecular Biology

Cite this

Adsorption of mutagens to chlorophyllin-chitosan, an insoluble form of chlorophyllin. / Arimoto, Sakae; Harada, Nanaho; Tokunaga, Risa; Odo, Jun Ichi; Hayatsu, Hikoya.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 381, No. 2, 28.11.1997, p. 243-249.

Research output: Contribution to journalArticle

Arimoto, Sakae ; Harada, Nanaho ; Tokunaga, Risa ; Odo, Jun Ichi ; Hayatsu, Hikoya. / Adsorption of mutagens to chlorophyllin-chitosan, an insoluble form of chlorophyllin. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1997 ; Vol. 381, No. 2. pp. 243-249.
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