Abstract
Chlorophyllin, a water soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic actions of compounds having polycyclic structures, e.g. heterocyclic amines and aflatoxin B1. There is evidence that this suppressing effect arises, at least in part, by a complex formation between the porphyrin-like structure of chlorophyllin and the planar molecular surfaces of these compounds. We report here that chlorophyllin can form an insoluble salt-like material when mixed with chitosan, a polyglucosamine, and that the solid chlorophyllin-chitosan thus prepared can efficiently trap polycyclic mutagenic compounds. The adsorbed polycyclic mutagens were elutable with buffers of acidic pH, but only to small extents. Chlorophyllin-chitosan may be expected to be useful as an intercepting agent against polycyclic mutagens and carcinogens.
| Original language | English |
|---|---|
| Pages (from-to) | 243-249 |
| Number of pages | 7 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 381 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 28 1997 |
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Keywords
- Adsorption
- Affinity separation
- Aflatoxin B
- Chitosan
- Chlorophyllin
- Heterocyclic amine
- Polycyclic mutagen
- Polyglacosamine
- Trp-P-2
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Molecular Biology
Cite this
Adsorption of mutagens to chlorophyllin-chitosan, an insoluble form of chlorophyllin. / Arimoto, Sakae; Harada, Nanaho; Tokunaga, Risa; Odo, Jun Ichi; Hayatsu, Hikoya.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 381, No. 2, 28.11.1997, p. 243-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adsorption of mutagens to chlorophyllin-chitosan, an insoluble form of chlorophyllin
AU - Arimoto, Sakae
AU - Harada, Nanaho
AU - Tokunaga, Risa
AU - Odo, Jun Ichi
AU - Hayatsu, Hikoya
PY - 1997/11/28
Y1 - 1997/11/28
N2 - Chlorophyllin, a water soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic actions of compounds having polycyclic structures, e.g. heterocyclic amines and aflatoxin B1. There is evidence that this suppressing effect arises, at least in part, by a complex formation between the porphyrin-like structure of chlorophyllin and the planar molecular surfaces of these compounds. We report here that chlorophyllin can form an insoluble salt-like material when mixed with chitosan, a polyglucosamine, and that the solid chlorophyllin-chitosan thus prepared can efficiently trap polycyclic mutagenic compounds. The adsorbed polycyclic mutagens were elutable with buffers of acidic pH, but only to small extents. Chlorophyllin-chitosan may be expected to be useful as an intercepting agent against polycyclic mutagens and carcinogens.
AB - Chlorophyllin, a water soluble derivative of chlorophyll, is known to suppress the mutagenic and carcinogenic actions of compounds having polycyclic structures, e.g. heterocyclic amines and aflatoxin B1. There is evidence that this suppressing effect arises, at least in part, by a complex formation between the porphyrin-like structure of chlorophyllin and the planar molecular surfaces of these compounds. We report here that chlorophyllin can form an insoluble salt-like material when mixed with chitosan, a polyglucosamine, and that the solid chlorophyllin-chitosan thus prepared can efficiently trap polycyclic mutagenic compounds. The adsorbed polycyclic mutagens were elutable with buffers of acidic pH, but only to small extents. Chlorophyllin-chitosan may be expected to be useful as an intercepting agent against polycyclic mutagens and carcinogens.
KW - Adsorption
KW - Affinity separation
KW - Aflatoxin B
KW - Chitosan
KW - Chlorophyllin
KW - Heterocyclic amine
KW - Polycyclic mutagen
KW - Polyglacosamine
KW - Trp-P-2
UR - http://www.scopus.com/inward/record.url?scp=0031589726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031589726&partnerID=8YFLogxK
U2 - 10.1016/S0027-5107(97)00188-7
DO - 10.1016/S0027-5107(97)00188-7
M3 - Article
C2 - 9434880
AN - SCOPUS:0031589726
VL - 381
SP - 243
EP - 249
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 2
ER -