AM is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and an amidated C-terminus, which are common to family members. Three types of AMs (AM1, AM2, and AM5) have been identified in mammals, although AM5 is mutated and impaired in some species, including humans, mice, and rats. AM is expressed ubiquitously in the body and exerts multiple effects. Vasodilation is the major function of AM derived from the vascular endothelial cells. Plasma AM levels are elevated in various diseases, such as chronic hypertension, congestive heart failure, ischemic heart injury, sepsis, cancers, renal impairment, and diabetes, which is useful for estimating the progression of disease. Am KO mice are embryonic lethal with abnormalities of vascular development.
|Title of host publication||Handbook of Hormones|
|Subtitle of host publication||Comparative Endocrinology for Basic and Clinical Research|
|Number of pages||3|
|Publication status||Published - Jan 1 2021|
- Multiple function
- Vascular endothelial cells and hypertension
ASJC Scopus subject areas