Adrenergic stimulation - Released histamine taken-up in adrenergic nerves induces endothelium-dependent vasodilation in rat mesenteric resistance arteries

Yuto Haruki, Shingo Takatori, Sayo Hattori, Yoshito Zamami, Toshihiro Koyama, Panot Tangsucharit, Hiromu Kawasaki

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4 Citations (Scopus)


The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene - related peptide (CGRP)ergic vasodilation and with active tone, PNS (1-4 Hz) induced only adrenergic nerve - mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.

Original languageEnglish
Pages (from-to)537-542
Number of pages6
JournalJournal of Pharmacological Sciences
Issue number4
Publication statusPublished - Oct 12 2012



  • Histamine
  • Perivascular adrenergic nerve
  • Rat mesenteric artery

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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