Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation

Kiyonori Yamaoka, Takaharu Nomura, Da Hong Wang, Shuji Mori, Takehito Taguchi, Tetsuya Ishikawa, Katsumi Hanamoto, Shohei Kira

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5 Citations (Scopus)

Abstract

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.

Original languageEnglish
Pages (from-to)133-144
Number of pages12
JournalPhysiological Chemistry and Physics and Medical NMR
Volume34
Issue number2
Publication statusPublished - 2002

Fingerprint

Dosimetry
Brain
Antioxidants
X-Rays
Irradiation
X rays
Catalase
Inbred C3H Mouse
Lipid Peroxides
Glutathione Peroxidase
Free radical reactions
Oxidative stress
Superoxide Dismutase
Free Radicals
Glutathione
Oxidative Stress
Blood
Oxygen
Enzymes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Biophysics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.",
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T1 - Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation

AU - Yamaoka, Kiyonori

AU - Nomura, Takaharu

AU - Wang, Da Hong

AU - Mori, Shuji

AU - Taguchi, Takehito

AU - Ishikawa, Tetsuya

AU - Hanamoto, Katsumi

AU - Kira, Shohei

PY - 2002

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