Abstract
The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.
| Original language | English |
|---|---|
| Pages (from-to) | 133-144 |
| Number of pages | 12 |
| Journal | Physiological Chemistry and Physics and Medical NMR |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - 2002 |
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ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Biophysics
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation. / Yamaoka, Kiyonori; Nomura, Takaharu; Wang, Da Hong; Mori, Shuji; Taguchi, Takehito; Ishikawa, Tetsuya; Hanamoto, Katsumi; Kira, Shohei.
In: Physiological Chemistry and Physics and Medical NMR, Vol. 34, No. 2, 2002, p. 133-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation
AU - Yamaoka, Kiyonori
AU - Nomura, Takaharu
AU - Wang, Da Hong
AU - Mori, Shuji
AU - Taguchi, Takehito
AU - Ishikawa, Tetsuya
AU - Hanamoto, Katsumi
AU - Kira, Shohei
PY - 2002
Y1 - 2002
N2 - The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.
AB - The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0043133384&partnerID=8YFLogxK
M3 - Article
C2 - 12841330
AN - SCOPUS:0043133384
VL - 34
SP - 133
EP - 144
JO - Physiological chemistry and physics
JF - Physiological chemistry and physics
SN - 0748-6642
IS - 2
ER -