ADIPOQ polymorphisms are associated with insulin resistance in Japanese women

Aya Kitamoto, Takuya Kitamoto, Rina So, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Takahiro Nakamura, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ikuo Mineo, Jun Wada, Yuji Ogawa, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki MasuzakiTakato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kikuko Hotta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Visceral fat accumulation contributes to the development of insulin resistance, leading to metabolic syndrome. Adiponectin provides a link between visceral fat accumulation and insulin resistance. In addition to environmental factors, genetic factors play important roles in visceral fat accumulation and circulating adiponectin levels. Genome-wide association studies (GWASs) have identified genetic variations in the adiponectin, C1Q and collagen domain containing (ADIPOQ) gene that are associated with adiponectin levels. In this study, we investigated whether ADIPOQ single nucleotide polymorphisms (SNPs) were associated with visceral fat accumulation and insulin resistance. We measured the visceral fat area (VFA) by computed tomography (CT) and examined the presence of the insulin resistance-related phenotype (fasting plasma glucose, fasting insulin, and homeostasis model assessment-insulin resistance [HOMA-IR]) in a set of Japanese individuals (731 men and 864 women) who were genotyped for seven ADIPOQ SNPs reported by recent GWASs (namely, rs6810075, rs10937273, rs1648707, rs864265, rs182052, rs17366568, and rs6773957). SNPs associated with the phenotype (P < 0.05) were then evaluated by association analysis using a second set of the study participants (383 men and 510 women). None of the SNPs was associated with body mass index (BMI) or VFA in men or women. However, the adiponectin-decreasing alleles of rs10937273 and rs1648707 were significantly associated with HOMA-IR (P = 0.0030 and P = 0.00074, respectively) in women, independently of BMI. These SNPs were significantly associated with decreased adiponectin levels in women. Our results suggested that rs10937273 and rs1648707 may affect insulin sensitivity by regulating adiponectin production by adipose tissue in women.

Original languageEnglish
Pages (from-to)513-521
Number of pages9
JournalEndocrine journal
Volume62
Issue number6
DOIs
Publication statusPublished - Apr 11 2015

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Keywords

  • ADIPOQ
  • Adiponectin
  • Insulin resistance
  • Single nucleotide polymorphism
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kitamoto, A., Kitamoto, T., So, R., Matsuo, T., Nakata, Y., Hyogo, H., Ochi, H., Nakamura, T., Kamohara, S., Miyatake, N., Kotani, K., Mineo, I., Wada, J., Ogawa, Y., Yoneda, M., Nakajima, A., Funahashi, T., Miyazaki, S., Tokunaga, K., ... Hotta, K. (2015). ADIPOQ polymorphisms are associated with insulin resistance in Japanese women. Endocrine journal, 62(6), 513-521. https://doi.org/10.1507/endocrj.EJ14-0574