Adhesion molecules and the extracellular matrix as drug targets for glioma

Toshihiko Shimizu, Kazuhiko Kurozumi, Joji Ishida, Tomotsugu Ichikawa, Isao Date

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


The formation of tumor vasculature and cell invasion along white matter tracts have pivotal roles in the development and progression of glioma. A better understanding of the mechanisms of angiogenesis and invasion in glioma will aid the development of novel therapeutic strategies. The processes of angiogenesis and invasion cause the production of an array of adhesion molecules and extracellular matrix (ECM) components. This review focuses on the role of adhesion molecules and the ECM in malignant glioma. The results of clinical trials using drugs targeted against adhesion molecules and the ECM for glioma are also discussed.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalBrain tumor pathology
Issue number2
Publication statusPublished - Apr 1 2016


  • Adhesion molecules
  • Angiogenesis
  • Extracellular matrix
  • Invasion
  • Malignant glioma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


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