Adherence characteristics and susceptibility to antimicrobial agents of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis

Hisanori Akiyama, Osamu Yamasaki, Joji Tada, Jirô Arata

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We examined the adherence characteristics and susceptibility to various antimicrobial agents of 130 strains of Staphylococcus aureus isolated from infective skin lesions and 135 strains of S. aureus isolated from non- infective eczematous lesions of atopic dermatitis (AD) patients. The isolation rate of methicillin-resistant S. aureus (MRSA) was 27.7% in strains from clinical sources excluding AD and 31.1% in those from AD. Coagulase type II strains were most frequently observed in MRSA strains isolated from all sources excluding AD, and coagulase type III strains were most frequently observed in those isolated from AD. We proposed that antimicrobial treatment for AD patients should be carefully designed to prevent MRSA infection. Plasma coagulation ability was lowest in S. aureus strains isolated from abscesses, suggesting that the lower production of fibrin observed in abscesses may assist the infiltration of neutrophils into skin tissues and that a decrease in plasma coagulation ability may enable abscess formation. Adherence to polypropylene tubes with slime production was most evident in S. aureus strains isolated from felon and least evident in those isolated from cellulitis and lymphangitis. Tube adherence was characteristic of the S. aureus strains attached to superficial skin tissues, but not necessarily for strains that had infiltrated the deep skin tissues. Fusidic acid demonstrated significant antimicrobial activity against the MRSA strains, but rifampicin was the strongest antimicrobial agent. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of Dermatological Science
Volume23
Issue number3
DOIs
Publication statusPublished - Aug 2000

Fingerprint

Atopic Dermatitis
Anti-Infective Agents
Staphylococcus aureus
Skin
Methicillin
Methicillin-Resistant Staphylococcus aureus
Infection
Abscess
Coagulase
Tissue
Coagulation
Lymphangitis
Fusidic Acid
Plasmas
Cellulitis
Neutrophil Infiltration
Polypropylenes
Rifampin
Fibrin
Infiltration

Keywords

  • Antimicrobial agents
  • Atopic dermatitis
  • Plasma coagulation ability
  • Skin infection
  • Staphylococcus aureus
  • Tube adherence

ASJC Scopus subject areas

  • Dermatology

Cite this

Adherence characteristics and susceptibility to antimicrobial agents of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis. / Akiyama, Hisanori; Yamasaki, Osamu; Tada, Joji; Arata, Jirô.

In: Journal of Dermatological Science, Vol. 23, No. 3, 08.2000, p. 155-160.

Research output: Contribution to journalArticle

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