Adduct formation between oxanine and amine derivatives.

T. Nakano, Hiroaki Terato, K. Asagoshi, Y. Ohyama, T. Suzuki, M. Yamada, K. Makino, H. Ide

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

Original languageEnglish
Pages (from-to)47-48
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number1
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

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Amines
Nitric Oxide
Spermidine
Guanine
Oligonucleotides
Lysine
DNA Damage
oxanine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakano, T., Terato, H., Asagoshi, K., Ohyama, Y., Suzuki, T., Yamada, M., ... Ide, H. (2001). Adduct formation between oxanine and amine derivatives. Nucleic acids research. Supplement (2001), (1), 47-48. https://doi.org/10.1093/nass/1.1.47

Adduct formation between oxanine and amine derivatives. / Nakano, T.; Terato, Hiroaki; Asagoshi, K.; Ohyama, Y.; Suzuki, T.; Yamada, M.; Makino, K.; Ide, H.

In: Nucleic acids research. Supplement (2001), No. 1, 01.01.2001, p. 47-48.

Research output: Contribution to journalArticle

Nakano, T, Terato, H, Asagoshi, K, Ohyama, Y, Suzuki, T, Yamada, M, Makino, K & Ide, H 2001, 'Adduct formation between oxanine and amine derivatives.', Nucleic acids research. Supplement (2001), no. 1, pp. 47-48. https://doi.org/10.1093/nass/1.1.47
Nakano, T. ; Terato, Hiroaki ; Asagoshi, K. ; Ohyama, Y. ; Suzuki, T. ; Yamada, M. ; Makino, K. ; Ide, H. / Adduct formation between oxanine and amine derivatives. In: Nucleic acids research. Supplement (2001). 2001 ; No. 1. pp. 47-48.
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