Abstract
Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.
| Original language | English |
|---|---|
| Pages (from-to) | 47-48 |
| Number of pages | 2 |
| Journal | Nucleic acids research. Supplement (2001) |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2001 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Adduct formation between oxanine and amine derivatives. / Nakano, T.; Terato, Hiroaki; Asagoshi, K.; Ohyama, Y.; Suzuki, T.; Yamada, M.; Makino, K.; Ide, H.
In: Nucleic acids research. Supplement (2001), No. 1, 01.01.2001, p. 47-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adduct formation between oxanine and amine derivatives.
AU - Nakano, T.
AU - Terato, Hiroaki
AU - Asagoshi, K.
AU - Ohyama, Y.
AU - Suzuki, T.
AU - Yamada, M.
AU - Makino, K.
AU - Ide, H.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.
AB - Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.
UR - http://www.scopus.com/inward/record.url?scp=0043206109&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0043206109&partnerID=8YFLogxK
U2 - 10.1093/nass/1.1.47
DO - 10.1093/nass/1.1.47
M3 - Article
C2 - 12836257
AN - SCOPUS:0043206109
SP - 47
EP - 48
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 1
ER -