Adduct formation between oxanine and amine derivatives.

T. Nakano; H. Terato; K. Asagoshi; Y. Ohyama; T. Suzuki; M. Yamada; K. Makino; H. Ide

doi:10.1093/nass/1.1.47

Adduct formation between oxanine and amine derivatives.

T. Nakano, H. Terato, K. Asagoshi, Y. Ohyama, T. Suzuki, M. Yamada, K. Makino, H. Ide

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

Original language	English
Pages (from-to)	47-48
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	1
DOIs	https://doi.org/10.1093/nass/1.1.47
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1093/nass/1.1.47

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AU - Terato, H.

AU - Asagoshi, K.

AU - Ohyama, Y.

AU - Suzuki, T.

AU - Yamada, M.

AU - Makino, K.

AU - Ide, H.

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AB - Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

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Adduct formation between oxanine and amine derivatives.

Abstract

ASJC Scopus subject areas

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