Adduct formation between oxanine and amine derivatives.

T. Nakano, H. Terato, K. Asagoshi, Y. Ohyama, T. Suzuki, M. Yamada, K. Makino, H. Ide

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

Original languageEnglish
Pages (from-to)47-48
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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