Adduct formation between oxanine and amine derivatives.

T. Nakano; H. Terato; K. Asagoshi; Y. Ohyama; T. Suzuki; M. Yamada; K. Makino; H. Ide

doi:10.1093/nass/1.1.47

Adduct formation between oxanine and amine derivatives.

T. Nakano, H. Terato, K. Asagoshi, Y. Ohyama, T. Suzuki, M. Yamada, K. Makino, H. Ide

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

Original language	English
Pages (from-to)	47-48
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	1
DOIs	https://doi.org/10.1093/nass/1.1.47
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1093/nass/1.1.47

Fingerprint Dive into the research topics of 'Adduct formation between oxanine and amine derivatives.'. Together they form a unique fingerprint.

Cite this

@article{0c931c86002a4840a71a32ac404a0ee6,

title = "Adduct formation between oxanine and amine derivatives.",

abstract = "Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.",

author = "T. Nakano and H. Terato and K. Asagoshi and Y. Ohyama and T. Suzuki and M. Yamada and K. Makino and H. Ide",

year = "2001",

doi = "10.1093/nass/1.1.47",

language = "English",

pages = "47--48",

journal = "Nucleic acids research. Supplement (2001)",

number = "1",

}

TY - JOUR

T1 - Adduct formation between oxanine and amine derivatives.

AU - Nakano, T.

AU - Terato, H.

AU - Asagoshi, K.

AU - Ohyama, Y.

AU - Suzuki, T.

AU - Yamada, M.

AU - Makino, K.

AU - Ide, H.

PY - 2001

Y1 - 2001

N2 - Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

AB - Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.

UR - http://www.scopus.com/inward/record.url?scp=0043206109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043206109&partnerID=8YFLogxK

U2 - 10.1093/nass/1.1.47

DO - 10.1093/nass/1.1.47

M3 - Article

C2 - 12836257

AN - SCOPUS:0043206109

SP - 47

EP - 48

JO - Nucleic acids research. Supplement (2001)

JF - Nucleic acids research. Supplement (2001)

IS - 1

ER -

Adduct formation between oxanine and amine derivatives.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this