Abstract
Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.
Original language | English |
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Pages (from-to) | 47-48 |
Number of pages | 2 |
Journal | Nucleic acids research. Supplement (2001) |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)