Additive effects of maternal high fat diet during lactation on mouse offspring

Hisashi Masuyama, Yuji Hiramatsu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Recent reports indicated that nutrition in early infancy might influence later child health outcomes such as obesity and metabolic syndrome. Therefore, we examined the effects of maternal high fat diet (HFD) during lactation on the onset of a metabolic syndrome in their offspring. All offspring were cross-fostered by dams on the same or opposite diet to yield 4 groups: offspring from HFD-fed dams suckled by HFD-fed dams (OHH) and by control diet (CD)-fed dams (OHC) and CD-fed dams suckled by HFD-fed dams (OCH) and by CD-fed dams (OCC) mice. We examined several metabolic syndrome-related factors including body weight, blood pressure, glucose tolerance and adipocytokines. Mean body weights of OHH and OCH mice were significantly higher than those of OHC and OCC mice, respectively, with elevated systolic blood pressure. Moreover, OHH and OCH mice revealed significantly worse glucose tolerance compared with the OHC and OCC mice, respectively. Triglyceride and leptin levels were significantly increased and adiponectin levels were significantly reduced by the maternal HFD during lactation, with similar changes in leptin and adiponectin mRNA expression but without histone modifications in adipose tissues. In addition, maternal obesity induced by HFD during lactation increased and prolonged the leptin surge in the offspring and the gender differences of leptin surge were observed. Our data suggested that maternal HFD during lactation might have an additive effect on the onset of the metabolic syndrome in the offspring, irrespective of the nutritional status in utero through the modified leptin surge.

Original languageEnglish
Article numbere92805
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 24 2014

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High Fat Diet
high fat diet
Nutrition
additive effect
Lactation
lactation
Fats
Mothers
Leptin
leptin
metabolic syndrome
mice
Dams
Diet
adiponectin
Adiponectin
glucose tolerance
Blood Pressure
diet
obesity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Additive effects of maternal high fat diet during lactation on mouse offspring. / Masuyama, Hisashi; Hiramatsu, Yuji.

In: PLoS One, Vol. 9, No. 3, e92805, 24.03.2014.

Research output: Contribution to journalArticle

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