Addition of platinum compounds to a new agent in patients with advanced non-smal-cell lung cancer: A literature based meta-analysis of randomised trials

K. Hotta, K. Matsuo, H. Ueoka, K. Kiura, M. Tabata, M. Tanimoto

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background: Single new agents reportedly produce promising response and survival effects, but platinum-based doublets remain the standard chemotherapy for advanced non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the effectiveness of platinum for advanced NSCLC by carrying out a meta-analysis of trials that compared platinum-based doublets with single new agent therapy alone. Methods: We carried out a literature search to identify trials, conducted between 1994 and 2003, comparing a doublet of platinum plus a new agent with a new agent alone in previously untreated patients with advanced NSCLC. Outcomes analysed were response, survival and toxicity. Results: Eight trials encompassing 2374 patients were identified. Platinum-based doublets produced an approximately two-fold higher overall (complete and partial) response rate than the new agent alone [odds ratio = 2.32; 95% confidence interval (CI) = 1.68-3.20]. Platinum-based doublet therapy was also associated with a 13% prolongation of survival (hazard ratio = 0.87; 95% CI = 0.80-0.94, P<0.001). Despite significant increases in the frequencies of various toxic effects in patients receiving platinum-based doublets, no significant difference in treatment-related mortality was observed. Conclusion: This is the first published meta-analysis demonstrating the importance of combining platinum with single new agents in the treatment of advanced NSCLC.

Original languageEnglish
Pages (from-to)1782-1789
Number of pages8
JournalAnnals of Oncology
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Doublets
  • Non-small-cell lung cancer
  • Platinum
  • Single-agent therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Addition of platinum compounds to a new agent in patients with advanced non-smal-cell lung cancer: A literature based meta-analysis of randomised trials'. Together they form a unique fingerprint.

Cite this