Add-on polytherapy with antidepressants and its significance in inpatients with major depression

Ken Wada, Norihito Yamada, Takashi Hamamura, Hiroshi Suzuki, Yoshiyuki Nakano, Shigetoshi Kuroda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Add-on polytherapy with antidepressant agents was reviewed in 42 inpatients with major depression diagnosed according to the ICD-10 criteria. Twenty-eight (67.7%) patients were treated with two or more antidepressants. The most frequent combination consisted of a tricyclic antidepressant and a non-tricyclic antidepressant. Nineteen (67.8%) patients of the polytherapy group were treated with a dosage equivalent to 150 mg/day of tricyclic antidepressant. Clinically, not every patient with major depression can tolerate the adverse side effects induced by an effective dose of a single tricyclic antidepressant. From this viewpoint, add-on polytherapy with antidepressants could be one of the treatment options, especially for such intolerant patients.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalPsychiatry and clinical neurosciences
Volume53
Issue number5
DOIs
Publication statusPublished - Oct 1 1999

Keywords

  • Antidepressants
  • Effective dose
  • Inpatient
  • Major depression
  • Polytherapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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