TY - JOUR
T1 - ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer
AU - Hata, Nanako
AU - Shigeyasu, Kunitoshi
AU - Umeda, Yuzo
AU - Yano, Shuya
AU - Takeda, Sho
AU - Yoshida, Kazuhiro
AU - Fuji, Tomokazu
AU - Yoshida, Ryuichi
AU - Yasui, Kazuya
AU - Umeda, Hibiki
AU - Takahashi, Toshiaki
AU - Kondo, Yoshitaka
AU - Kishimoto, Hiroyuki
AU - Mori, Yoshiko
AU - Teraishi, Fuminori
AU - Yamamoto, Hideki
AU - Michiue, Hiroyuki
AU - Nakamura, Keiichiro
AU - Tazawa, Hiroshi
AU - Fujiwara, Toshiyoshi
N1 - Funding Information:
This study was supported by grants from Takeda Science Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research, and JSPS KAKENHI (20K17653) to KS, from JSPS KAKENHI (20K22848, 22K16533) to ST, and from JSPS KAKENHI (21K16422) to Y. Kondo.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers. However, the clinical significance of RNA editing in patients with liver metastasis from colorectal cancer (CRC) remains unclear. The current study aimed to systematically and comprehensively investigate the significance of adenosine deaminase acting on RNA 1 (ADAR1) expression status in 83 liver metastatic tissue samples collected from 36 patients with CRC. The ADAR1 expression level was significantly elevated in liver metastatic tissue samples obtained from patients with right-sided, synchronous, or RAS mutant-type CRC. ADAR1-high liver metastasis was significantly correlated with remnant liver recurrence after hepatic metastasectomy. A high ADAR1 expression was a predictive factor of remnant liver recurrence (area under the curve = 0.72). Results showed that the ADAR1 expression level could be a clinically relevant predictive indicator of remnant liver recurrence. Patients with liver metastases who have a high ADAR1 expression requires adjuvant chemotherapy after hepatic metastasectomy.
AB - Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers. However, the clinical significance of RNA editing in patients with liver metastasis from colorectal cancer (CRC) remains unclear. The current study aimed to systematically and comprehensively investigate the significance of adenosine deaminase acting on RNA 1 (ADAR1) expression status in 83 liver metastatic tissue samples collected from 36 patients with CRC. The ADAR1 expression level was significantly elevated in liver metastatic tissue samples obtained from patients with right-sided, synchronous, or RAS mutant-type CRC. ADAR1-high liver metastasis was significantly correlated with remnant liver recurrence after hepatic metastasectomy. A high ADAR1 expression was a predictive factor of remnant liver recurrence (area under the curve = 0.72). Results showed that the ADAR1 expression level could be a clinically relevant predictive indicator of remnant liver recurrence. Patients with liver metastases who have a high ADAR1 expression requires adjuvant chemotherapy after hepatic metastasectomy.
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U2 - 10.1038/s41598-023-29397-z
DO - 10.1038/s41598-023-29397-z
M3 - Article
C2 - 36747029
AN - SCOPUS:85147461241
SN - 2045-2322
VL - 13
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 2078
ER -
