Abstract
Bacteria and mammalian cells show an adaptive response to oxidative stress. Pre-treatment with small amounts of oxidant induces resistance to the subsequent, otherwise lethal, doses of oxidant. Previous studies have shown that this adaptive response involves the induction of superoxide dismutase (SOD), glutathione peroxidase (GPX), metallothionein, heat shock proteins, and other factors. The toxicity of ionizing radiation, particularly at low doses, to living cells, is thought to be due to reactive oxygen species (ROS) formation. Thus, adaptive responses to low doses of ionizing radiation and to oxidants are likely to be similar. In this paper, the induction of endogenous glutathione (GSH) together with antioxidant enzymes induced by low-dose radiation was reviewed. Furthermore, the applicable possibility of this efficacy for the prevention of and/or therapy of various reactive oxygen species (ROS)-related diseases including Parkinson's diseases, aging, and diabetes, was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 133-143 |
| Number of pages | 11 |
| Journal | Journal of Health Science |
| Volume | 45 |
| Issue number | 3 |
| Publication status | Published - 1999 |
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Keywords
- Adaptive response
- Antioxidant enzyme
- Glutathione
- Low dose radiation
- ROS-related disease
- Therapy
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Toxicology
Cite this
Adaptive responses of living cells towards low-doses of radiation; induction of endogenous antioxidant system and its applicable possibility for treatment of diseases. / Kojima, Shuji; Yamaoka, Kiyonori.
In: Journal of Health Science, Vol. 45, No. 3, 1999, p. 133-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adaptive responses of living cells towards low-doses of radiation; induction of endogenous antioxidant system and its applicable possibility for treatment of diseases
AU - Kojima, Shuji
AU - Yamaoka, Kiyonori
PY - 1999
Y1 - 1999
N2 - Bacteria and mammalian cells show an adaptive response to oxidative stress. Pre-treatment with small amounts of oxidant induces resistance to the subsequent, otherwise lethal, doses of oxidant. Previous studies have shown that this adaptive response involves the induction of superoxide dismutase (SOD), glutathione peroxidase (GPX), metallothionein, heat shock proteins, and other factors. The toxicity of ionizing radiation, particularly at low doses, to living cells, is thought to be due to reactive oxygen species (ROS) formation. Thus, adaptive responses to low doses of ionizing radiation and to oxidants are likely to be similar. In this paper, the induction of endogenous glutathione (GSH) together with antioxidant enzymes induced by low-dose radiation was reviewed. Furthermore, the applicable possibility of this efficacy for the prevention of and/or therapy of various reactive oxygen species (ROS)-related diseases including Parkinson's diseases, aging, and diabetes, was discussed.
AB - Bacteria and mammalian cells show an adaptive response to oxidative stress. Pre-treatment with small amounts of oxidant induces resistance to the subsequent, otherwise lethal, doses of oxidant. Previous studies have shown that this adaptive response involves the induction of superoxide dismutase (SOD), glutathione peroxidase (GPX), metallothionein, heat shock proteins, and other factors. The toxicity of ionizing radiation, particularly at low doses, to living cells, is thought to be due to reactive oxygen species (ROS) formation. Thus, adaptive responses to low doses of ionizing radiation and to oxidants are likely to be similar. In this paper, the induction of endogenous glutathione (GSH) together with antioxidant enzymes induced by low-dose radiation was reviewed. Furthermore, the applicable possibility of this efficacy for the prevention of and/or therapy of various reactive oxygen species (ROS)-related diseases including Parkinson's diseases, aging, and diabetes, was discussed.
KW - Adaptive response
KW - Antioxidant enzyme
KW - Glutathione
KW - Low dose radiation
KW - ROS-related disease
KW - Therapy
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M3 - Article
VL - 45
SP - 133
EP - 143
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 3
ER -