ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

Tuna L. Hurskainen, Satoshi Hirohata, Michael F. Seldin, Suneel S. Apte

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

We report the primary structure of three novel, putative zinc metalloproteases designated ADAM-TS5, ADAM-TS6, and ADAM-TS7. All have a similar domain organization, comprising a preproregion, a reprolysin-type catalytic domain, a disintegrin-like domain, a thrombospondin type-1 (TS) module, a cysteine-rich domain, a spacer domain without cysteine residues, and a COOH-terminal TS module. These genes are differentially regulated during mouse embryogenesis and in adult tissues, with Adamts5 highly expressed in the peri-implantation period in embryo and trophoblast. These proteins are similar to four other cognate gene products, defining a distinct family of human reprolysin-like metalloproteases, the ADAM-TS family. The other members of the family are ADAM-TS1, an inflammation-induced gene, the procollagen I/II amino-propeptide processing enzyme (PCINP, ADAM-TS2), and proteins predicted by the KIAA0366 and KIAA0688 genes (ADAMTS3 and ADAM-TS4). Individual ADAM-TS members differ in the number of COOH-terminal TS modules, and some have unique COOH-terminal domains. The ADAM-TS genes are dispersed in human and mouse genomes.

Original languageEnglish
Pages (from-to)25555-25563
Number of pages9
JournalJournal of Biological Chemistry
Volume274
Issue number36
DOIs
Publication statusPublished - Sep 3 1999
Externally publishedYes

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Metalloproteases
Zinc
Genes
Cysteine
ADAM Proteins
Thrombospondin 1
Disintegrins
Procollagen
Trophoblasts
Human Genome
Embryonic Development
Catalytic Domain
Embryonic Structures
Inflammation
Proteins
Tissue
Enzymes
Processing

ASJC Scopus subject areas

  • Biochemistry

Cite this

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. / Hurskainen, Tuna L.; Hirohata, Satoshi; Seldin, Michael F.; Apte, Suneel S.

In: Journal of Biological Chemistry, Vol. 274, No. 36, 03.09.1999, p. 25555-25563.

Research output: Contribution to journalArticle

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