Acute posterior multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis

Toshihiko Matsuo, Toshiko Horikoshi, Chieko Nagai

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasmic antibody)-positive systemic vasculitis. DESIGN: Interventional case report.METHODS: A 69-year-old woman developed bilateral acute posterior multifocal placoid pigment epitheliopathy concurrent with rapidly progressive glomerulonephritis and bronchioalveolitis in both lungs.RESULTS: The patient showed a high titer of pANCA (myeloperoxidase-ANCA). She then developed scleritis in the left eye and multiple gastric ulcers. CONCLUSION: Acute posterior multifocal placoid pigment epitheliopathy and scleritis in this patient are manifestations that are part of pANCA-positive systemic vasculitis. This association further supports that acute posterior multifocal placoid pigment epitheliopathy is caused by vasculitic inflammation of the choriocapillaris.

Original languageEnglish
Pages (from-to)566-568
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume133
Issue number4
DOIs
Publication statusPublished - 2002

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Scleritis
Systemic Vasculitis
Antineutrophil Cytoplasmic Antibodies
Stomach Ulcer
Glomerulonephritis
Peroxidase
Inflammation
Lung

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Acute posterior multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis. / Matsuo, Toshihiko; Horikoshi, Toshiko; Nagai, Chieko.

In: American Journal of Ophthalmology, Vol. 133, No. 4, 2002, p. 566-568.

Research output: Contribution to journalArticle

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AB - PURPOSE: To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasmic antibody)-positive systemic vasculitis. DESIGN: Interventional case report.METHODS: A 69-year-old woman developed bilateral acute posterior multifocal placoid pigment epitheliopathy concurrent with rapidly progressive glomerulonephritis and bronchioalveolitis in both lungs.RESULTS: The patient showed a high titer of pANCA (myeloperoxidase-ANCA). She then developed scleritis in the left eye and multiple gastric ulcers. CONCLUSION: Acute posterior multifocal placoid pigment epitheliopathy and scleritis in this patient are manifestations that are part of pANCA-positive systemic vasculitis. This association further supports that acute posterior multifocal placoid pigment epitheliopathy is caused by vasculitic inflammation of the choriocapillaris.

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