Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5

Akihiro Abe, Mitsune Tanimoto, Masayuki Towatari, Akira Matsuoka, Kenjiro Kitaori, Hidefumi Kato, Hisato Toyozumi, Takaaki Takeo, Koichi Adachi, Nobuhiko Emi, Kohei Kawashima, Hidehiko Saito

Research output: Contribution to journalArticle

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Abstract

We present an 18-year-old woman who was diagnosed with acute myeloblastic leukemia (AML M2), and in whom chromosome analysis of bone marrow cells revealed t(7;11), an abnormality rarely found in leukemias with a differentiation potency. She relapsed 1 year after complete remission was achieved by chemotherapy. Bone marrow examination then revealed a t(7;11) abnormality in 48 of 50 metaphases examined, even when there were less than 7.5% leukemic blasts in the marrow, indicating that the morphologically normal cells were derived from leukemic blasts. The number of leukemia clones with the additional abnormalities in chromosome 5 increased, with concurrent development of eosinophilia, fever, asthma-like symptoms, erythema, itching, and hepatosplenomegaly. Elevation of interleukin 5 (IL-5) in serum and an enhanced expression of IL-5 mRNA were also detected. The increase in IL-5 may have been produced by an abnormality on chromosome 5.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume83
Issue number1
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Chromosomes, Human, Pair 5
Interleukin-5
Eosinophilia
Acute Myeloid Leukemia
Leukemia
Bone Marrow Examination
Erythema
Pruritus
Metaphase
Bone Marrow Cells
Fever
Asthma
Clone Cells
Chromosomes
Bone Marrow
Drug Therapy
Messenger RNA
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5. / Abe, Akihiro; Tanimoto, Mitsune; Towatari, Masayuki; Matsuoka, Akira; Kitaori, Kenjiro; Kato, Hidefumi; Toyozumi, Hisato; Takeo, Takaaki; Adachi, Koichi; Emi, Nobuhiko; Kawashima, Kohei; Saito, Hidehiko.

In: Cancer Genetics and Cytogenetics, Vol. 83, No. 1, 1995, p. 37-41.

Research output: Contribution to journalArticle

Abe, A, Tanimoto, M, Towatari, M, Matsuoka, A, Kitaori, K, Kato, H, Toyozumi, H, Takeo, T, Adachi, K, Emi, N, Kawashima, K & Saito, H 1995, 'Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5', Cancer Genetics and Cytogenetics, vol. 83, no. 1, pp. 37-41. https://doi.org/10.1016/S0165-4608(95)00021-6
Abe, Akihiro ; Tanimoto, Mitsune ; Towatari, Masayuki ; Matsuoka, Akira ; Kitaori, Kenjiro ; Kato, Hidefumi ; Toyozumi, Hisato ; Takeo, Takaaki ; Adachi, Koichi ; Emi, Nobuhiko ; Kawashima, Kohei ; Saito, Hidehiko. / Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5. In: Cancer Genetics and Cytogenetics. 1995 ; Vol. 83, No. 1. pp. 37-41.
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