Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5

Akihiro Abe, Mitsune Tanimoto, Masayuki Towatari, Akira Matsuoka, Kenjiro Kitaori, Hidefumi Kato, Hisato Toyozumi, Takaaki Takeo, Koichi Adachi, Nobuhiko Emi, Kohei Kawashima, Hidehiko Saito

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16 Citations (Scopus)

Abstract

We present an 18-year-old woman who was diagnosed with acute myeloblastic leukemia (AML M2), and in whom chromosome analysis of bone marrow cells revealed t(7;11), an abnormality rarely found in leukemias with a differentiation potency. She relapsed 1 year after complete remission was achieved by chemotherapy. Bone marrow examination then revealed a t(7;11) abnormality in 48 of 50 metaphases examined, even when there were less than 7.5% leukemic blasts in the marrow, indicating that the morphologically normal cells were derived from leukemic blasts. The number of leukemia clones with the additional abnormalities in chromosome 5 increased, with concurrent development of eosinophilia, fever, asthma-like symptoms, erythema, itching, and hepatosplenomegaly. Elevation of interleukin 5 (IL-5) in serum and an enhanced expression of IL-5 mRNA were also detected. The increase in IL-5 may have been produced by an abnormality on chromosome 5.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume83
Issue number1
DOIs
Publication statusPublished - Aug 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Abe, A., Tanimoto, M., Towatari, M., Matsuoka, A., Kitaori, K., Kato, H., Toyozumi, H., Takeo, T., Adachi, K., Emi, N., Kawashima, K., & Saito, H. (1995). Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5. Cancer Genetics and Cytogenetics, 83(1), 37-41. https://doi.org/10.1016/S0165-4608(95)00021-6