Acute Limb Ischemia does not Facilitate but Inhibits Norepinephrine Release from Muscle Sympathetic Nerve Endings in Anesthetized Rabbit

Noriyuki Tokunaga, Toji Yamazaki, Tsuyoshi Akiyama, Shunji Sano, Hidezo Mori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate norepinephrine levels as an index of muscle sympathetic nerve activity. Acute hindlimb ischemia was induced by injection of microspheres and occlusion of the common iliac artery. Dialysate norepinephrine levels decreased from 19.3 ± 3.5 pg/ml at control to 9.4 ± 3.7 pg/ml at 30 min of ischemia and further to 1.7 ± 0,2 pg/ml at 75 min of ischemia. During acute hindlimb ischemia, baroreflex (bilateral carotid occlusion) and high potassium level-induced norepinephrine response was inhibited, but tyramine-induced norepinephrine response was preserved. In conclusion, acute hindlimb ischemia caused decreases in dialysate norepinephrine levels. This reduction may be mediated by an impairment of axonal conduction and/or of norepinephrine releasing function at skeletal muscle sympathetic nerve endings.

Original languageEnglish
Pages (from-to)S7-S10
JournalJournal of cardiovascular pharmacology
Volume42
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Acute limb ischemia
  • Muscle sympathetic nerve
  • Norepinephrine release

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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