Acute kidney injury caused by evans syndrome with systemic lupus erythematosus and systemic sclerosis

Natsumi Matsuoka, Haruki Watanabe, Naoko Kurooka, Sumari Kato, Chika Higashi, Katsuyuki Tanabe, Masaru Kinomura, Nobuharu Fujii, Ken Ei Sada, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journalArticlepeer-review

Abstract

A 65-year-old woman with systemic sclerosis and systemic lupus erythematosus developed acute kidney injury (AKI), Coombs-positive autoimmune hemolytic anemia and autoimmune thrombocytopenia; therefore, she was diagnosed with Evans syndrome (ES). Intravascular hemolysis was suggested as the cause of AKI based on the presence of acute tubular injury and trace hemosiderin deposits on the renal biopsy. The renal function, hemolytic anemia and thrombocytopenia were restored by an increased dose of glucocorticoids, hemodialysis, and plasma exchange. Although ES with severe hemolytic anemia is very rare, it is important to detect possible renal dysfunction when encountering patients with severe hemolysis.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalInternal Medicine
Volume60
Issue number7
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Acute kidney injury
  • Autoimmune hemolytic anemia
  • Evans syndrome

ASJC Scopus subject areas

  • Internal Medicine

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