Acute hepatitis due to hepatitis e virus genotype 1 as an imported infectious disease in Japan

Koji Miyahara, Yasuhiro Miyake, Tetsuya Yasunaka, Fusao Ikeda, Akinobu Takaki, Yoshiaki Iwasaki, Haruhiko Kobashi, Jong Hon Kang, Kazuaki Takahashi, Masahiro Arai, Kazuhide Yamamoto

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Abstract

An 18-year-old Nepalese man was admitted due to general malaise and anorexia a month after coming to Japan. Laboratory tests showed elevation of transaminase and positivity for IgM anti-HEV antibody. Serum HEV RNA was detected by RT-PCR amplifications. An HEV genome phylogenetic tree, constructed using an 821-nucleotide sequence in the open reading frame 1, indicated that the genotype was 1. HEV genotype 1 is epidemic in South Asia, Africa and South America, and the incidence of acute hepatitis due to HEV genotype 1 is low in Japan. Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease.

Original languageEnglish
Pages (from-to)2613-2616
Number of pages4
JournalInternal Medicine
Volume49
Issue number23
DOIs
Publication statusPublished - Dec 10 2010

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Keywords

  • Acute hepatitis
  • Genotype
  • Hepatitis E virus

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Miyahara, K., Miyake, Y., Yasunaka, T., Ikeda, F., Takaki, A., Iwasaki, Y., Kobashi, H., Kang, J. H., Takahashi, K., Arai, M., & Yamamoto, K. (2010). Acute hepatitis due to hepatitis e virus genotype 1 as an imported infectious disease in Japan. Internal Medicine, 49(23), 2613-2616. https://doi.org/10.2169/internalmedicine.49.4221