Acute flaccid myelitis associated with enterovirus D68 in a non-epidemic setting

Kazuki Hatayama, Shinichiro Goto, Masato Yashiro, Harushi Mori, Tsuguto Fujimoto, Nozomu Hanaoka, Keiko Tanaka-Taya, Tomoka Zuzan, Masaru Inoue

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Acute flaccid myelitis (AFM)is a recently defined clinical disease accompanied by the national outbreak of enterovirus D68 (EV-D68)in the United States during the late summer/fall of 2014; 258 cases of EV-D68 and 59 cases of AFM were reported in Japan during the late summer/fall of 2015. Subsequently, there have been no epidemics of AFM or EV-D68. However, we encountered a patient who had AFM associated with EV-D68 in 2017. This is the first case of AFM caused by EV-D68 after the 2015 epidemic, and the only reported case in 2017. This report indicates that AFM caused by EV-D68 can arise even in non-epidemic situations. If a patient presents with paralysis, AFM caused by EV-D68 should be included in the differential diagnosis, regardless of the absence of an epidemic of EV-D68 infection.

Original languageEnglish
Article numbere00549
Publication statusPublished - Jan 1 2019



  • Acute flaccid myelitis
  • Enterovirus D68

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Hatayama, K., Goto, S., Yashiro, M., Mori, H., Fujimoto, T., Hanaoka, N., Tanaka-Taya, K., Zuzan, T., & Inoue, M. (2019). Acute flaccid myelitis associated with enterovirus D68 in a non-epidemic setting. IDCases, 17, [e00549].