Acute exposure to sulfur dioxide and mortality: Historical data from Yokkaichi, Japan

Takashi Yorifuji, Saori Kashima, Made Ayu Hitapretiwi Suryadhi, Kawuli Abudureyimu

Research output: Contribution to journalArticle

1 Citation (Scopus)


We examined the association between acute exposure to sulfur dioxide (SO2) and mortality, using historical data from 1972–1991 in Yokkaichi, Japan. We used a time-stratified case-crossover study design. We included all causes of death, excluding external causes, between 1972 and 1991 in Yokkaichi and the neighboring town, Kusu of the Mie Prefecture (N = 29,839). We obtained daily estimations of SO2 concentrations during the study period. We then conducted conditional logistic regression analysis to examine association between SO2 exposure and all-cause and cause-specific mortality. Exposure to SO2 increased the risk of all-cause and cause-specific mortality in a non-linear manner. The relationship between SO2 exposure and mortality outcomes remained after adjustment for co-pollutants such as particulate matter and nitrogen dioxide. Historical data from Yokkaichi, Japan, showed that SO2 exposure increased the risk of all-cause and cause-specific mortality.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalArchives of Environmental and Occupational Health
Publication statusAccepted/In press - Feb 19 2018



  • Air pollution
  • Cardiovascular disease
  • Epidemiology
  • Respiratory disease
  • sulfur dioxide
  • Yokkaichi Asthma

ASJC Scopus subject areas

  • Toxicology
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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