Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model

Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novelADmodel (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 +HP group (n = 12) than the simple APP23 (n = 10) group (∗p < 0.05 and ∗ ∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF-dependent AHSG in a novel AD plus HP mice model.

Original languageEnglish
Pages (from-to)1667-1675
Number of pages9
JournalJournal of Alzheimer's Disease
Volume68
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

alpha-2-HS-Glycoprotein
Alzheimer Disease
Anti-Inflammatory Agents
Brain
Thalamus
Neurodegenerative Diseases
Cerebral Cortex
Dementia
Hippocampus
Up-Regulation
Down-Regulation
Tumor Necrosis Factor-alpha
Pathology
Inflammation
inter-alpha-inhibitor
mouse countertrypin protein

Keywords

  • AHSG
  • Alzheimer's disease
  • APP23 mice
  • Hypoperfusion
  • Inflammation
  • ITIH4

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model. / Shi, Xiaowen; Ohta, Yasuyuki; Liu, Xia; Shang, Jingwei; Morihara, Ryuta; Nakano, Yumiko; Feng, Tian; Huang, Yong; Sato, Kota; Takemoto, Mami; Hishikawa, Nozomi; Yamashita, Toru; Abe, Koji.

In: Journal of Alzheimer's Disease, Vol. 68, No. 4, 01.01.2019, p. 1667-1675.

Research output: Contribution to journalArticle

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