Actual Status of Involvement of Helicobacter pylori Infection That Developed Gastric Cancer from Group A of ABC (D) Stratification - Study of Early Gastric Cancer Cases That Underwent Endoscopic Submucosal Dissection

Ko Miura, Hiroyuki Okada, Yoshiyasu Kouno, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A′). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A′ than in other groups. Group A′ scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalDigestion
DOIs
Publication statusAccepted/In press - Jun 23 2016

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Pepsinogen A
Atrophy
Infection
Antibodies
Gastric Mucosa
Endoscopic Mucosal Resection
Neutrophils
Inflammation
Biopsy

Keywords

  • ABC (D) stratification
  • Gastric cancer
  • Group A
  • Helicobacter pylori
  • Pepsinogen

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{999e5e3af7114641828af86756ef8870,
title = "Actual Status of Involvement of Helicobacter pylori Infection That Developed Gastric Cancer from Group A of ABC (D) Stratification - Study of Early Gastric Cancer Cases That Underwent Endoscopic Submucosal Dissection",
abstract = "Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A′). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A′ than in other groups. Group A′ scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk.",
keywords = "ABC (D) stratification, Gastric cancer, Group A, Helicobacter pylori, Pepsinogen",
author = "Ko Miura and Hiroyuki Okada and Yoshiyasu Kouno and Hiromitsu Kanzaki and Masaya Iwamuro and Keisuke Hori and Masahide Kita and Seiji Kawano and Yoshiro Kawahara and Takehiro Tanaka and Hiroyuki Yanai",
year = "2016",
month = "6",
day = "23",
doi = "10.1159/000446771",
language = "English",
pages = "17--23",
journal = "Digestion",
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T1 - Actual Status of Involvement of Helicobacter pylori Infection That Developed Gastric Cancer from Group A of ABC (D) Stratification - Study of Early Gastric Cancer Cases That Underwent Endoscopic Submucosal Dissection

AU - Miura, Ko

AU - Okada, Hiroyuki

AU - Kouno, Yoshiyasu

AU - Kanzaki, Hiromitsu

AU - Iwamuro, Masaya

AU - Hori, Keisuke

AU - Kita, Masahide

AU - Kawano, Seiji

AU - Kawahara, Yoshiro

AU - Tanaka, Takehiro

AU - Yanai, Hiroyuki

PY - 2016/6/23

Y1 - 2016/6/23

N2 - Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A′). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A′ than in other groups. Group A′ scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk.

AB - Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A′). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A′ than in other groups. Group A′ scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk.

KW - ABC (D) stratification

KW - Gastric cancer

KW - Group A

KW - Helicobacter pylori

KW - Pepsinogen

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