Activity of neurons in the nucleus of the solitary tract of rats

Effect of osmotic and mechanical stimuli

Shunji Izawa, Kiyoshi Inoue, Akira Adachi, Makoto Funahashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Patch-clamp recordings were used to examine the osmosensitivity and mechanosensitivity of neurons in the caudal part of the nucleus tractus solitarius in coronal slices from rat brain. Firing rates and membrane potentials were measured as slices were exposed to perfusate which varied in its osmolality and/or sodium concentration. In all cells tested, the responses to change in the sodium concentration of perfusate were duplicated by osmolality changes of sucrose or mannitol. When nucleus tractus solitarius cells were tested with changes in pressure applied via the pipette, responses to positive or negative pressure paralleled their responses to osmotic stimulation. We suggest that a mechanosensitive receptor exists on osmosensitive neurons within the nucleus tractus solitarius, and this receptor may be responsible for changes in the firing rate and membrane potential which occur in the nucleus tractus solitarius neurons. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume288
Issue number1
DOIs
Publication statusPublished - Jul 7 2000

Fingerprint

Solitary Nucleus
Neurons
Membrane Potentials
Osmolar Concentration
Sodium
Pressure
Mannitol
Sucrose
Brain

Keywords

  • Brain slices
  • Mechanosensitivity
  • Nucleus tractus solitarius
  • Osmosensitivity
  • Rat
  • Whole-cell current-clamp

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activity of neurons in the nucleus of the solitary tract of rats : Effect of osmotic and mechanical stimuli. / Izawa, Shunji; Inoue, Kiyoshi; Adachi, Akira; Funahashi, Makoto.

In: Neuroscience Letters, Vol. 288, No. 1, 07.07.2000, p. 33-36.

Research output: Contribution to journalArticle

Izawa, Shunji ; Inoue, Kiyoshi ; Adachi, Akira ; Funahashi, Makoto. / Activity of neurons in the nucleus of the solitary tract of rats : Effect of osmotic and mechanical stimuli. In: Neuroscience Letters. 2000 ; Vol. 288, No. 1. pp. 33-36.
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