Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease.

N. Miyoshi, Shin-ichi Miyoshi, K. Sugiyama, Y. Suzuki, H. Furuta, S. Shinoda

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Vibrio vulnificus protease enhanced hypodermic vascular permeability when injected into the dorsal skin of a guinea pig. Enhancement of permeability was observed within 2 min, and the permeability-enhancing reaction terminated at about 10 min postinjection. The permeability-enhancing reaction was greatly augmented by simultaneous injection of a kininase II inhibitor, whereas the reaction was inhibited by soybean trypsin inhibitor, a well-known inhibitor of plasma kallikrein. Furthermore, in vitro activation of plasma prekallikrein to kallikrein by V. vulnificus protease was observed. These results indicate that V. vulnificus protease enhances vascular permeability through activation of the plasma kallikrein-kinin system which generates bradykinin, factor in edema formation.

Original languageEnglish
Pages (from-to)1936-1939
Number of pages4
JournalInfection and Immunity
Volume55
Issue number8
Publication statusPublished - Aug 1987
Externally publishedYes

Fingerprint

Vibrio vulnificus
Plasma Kallikrein
Kallikrein-Kinin System
Permeability
Peptide Hydrolases
Capillary Permeability
Prekallikrein
Kallikreins
Trypsin Inhibitors
Bradykinin
Soybeans
Angiotensin-Converting Enzyme Inhibitors
Guinea Pigs
Skin
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Miyoshi, N., Miyoshi, S., Sugiyama, K., Suzuki, Y., Furuta, H., & Shinoda, S. (1987). Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease. Infection and Immunity, 55(8), 1936-1939.

Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease. / Miyoshi, N.; Miyoshi, Shin-ichi; Sugiyama, K.; Suzuki, Y.; Furuta, H.; Shinoda, S.

In: Infection and Immunity, Vol. 55, No. 8, 08.1987, p. 1936-1939.

Research output: Contribution to journalArticle

Miyoshi, N, Miyoshi, S, Sugiyama, K, Suzuki, Y, Furuta, H & Shinoda, S 1987, 'Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease.', Infection and Immunity, vol. 55, no. 8, pp. 1936-1939.
Miyoshi N, Miyoshi S, Sugiyama K, Suzuki Y, Furuta H, Shinoda S. Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease. Infection and Immunity. 1987 Aug;55(8):1936-1939.
Miyoshi, N. ; Miyoshi, Shin-ichi ; Sugiyama, K. ; Suzuki, Y. ; Furuta, H. ; Shinoda, S. / Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease. In: Infection and Immunity. 1987 ; Vol. 55, No. 8. pp. 1936-1939.
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