Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition

Yuki Takayanagi, Masahide Yoshida, Akihide Takashima, Keiko Takanami, Shoma Yoshida, Katsuhiko Nishimori, Ichiko Nishijima, Hirotaka Sakamoto, Takanori Yamagata, Tatsushi Onaka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Social recognition underlies social behavior in animals, and patients with psychiatric disorders associated with social deficits show abnormalities in social recognition. Oxytocin is implicated in social behavior and has received attention as an effective treatment for sociobehavioral deficits. Secretin receptor-deficient mice show deficits in social behavior. The relationship between oxytocin and secretin concerning social behavior remains to be determined. Methods: Expression of c-Fos in oxytocin neurons and release of oxytocin from their dendrites after secretin application were investigated. Social recognition was examined after intracerebroventricular or local injection of secretin, oxytocin, or an oxytocin receptor antagonist in rats, oxytocin receptor-deficient mice, and secretin receptor-deficient mice. Electron and light microscopic immunohistochemical analysis was also performed to determine whether oxytocin neurons extend their dendrites into the medial amygdala. Results: Supraoptic oxytocin neurons expressed the secretin receptor. Secretin activated supraoptic oxytocin neurons and facilitated oxytocin release from dendrites. Secretin increased acquisition of social recognition in an oxytocin receptor-dependent manner. Local application of secretin into the supraoptic nucleus facilitated social recognition, and this facilitation was blocked by an oxytocin receptor antagonist injected into, but not outside of, the medial amygdala. In the medial amygdala, dendrite-like thick oxytocin processes were found to extend from the supraoptic nucleus. Furthermore, oxytocin treatment restored deficits of social recognition in secretin receptor-deficient mice. Conclusions: The results of our study demonstrate that secretin-induced dendritic oxytocin release from supraoptic neurons enhances social recognition. The newly defined secretin-oxytocin system may lead to a possible treatment for social deficits.

Original languageEnglish
JournalBiological Psychiatry
DOIs
Publication statusAccepted/In press - Jun 15 2015

Fingerprint

Secretin
Oxytocin
Neurons
Social Behavior
Oxytocin Receptors
Dendrites
Amygdala
Supraoptic Nucleus
Social Facilitation
Psychiatry
Therapeutics

Keywords

  • Dendritic release
  • Medial amygdala
  • Oxytocin
  • Secretin
  • Social recognition
  • Supraoptic nucleus

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Takayanagi, Y., Yoshida, M., Takashima, A., Takanami, K., Yoshida, S., Nishimori, K., ... Onaka, T. (Accepted/In press). Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2015.11.021

Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition. / Takayanagi, Yuki; Yoshida, Masahide; Takashima, Akihide; Takanami, Keiko; Yoshida, Shoma; Nishimori, Katsuhiko; Nishijima, Ichiko; Sakamoto, Hirotaka; Yamagata, Takanori; Onaka, Tatsushi.

In: Biological Psychiatry, 15.06.2015.

Research output: Contribution to journalArticle

Takayanagi, Y, Yoshida, M, Takashima, A, Takanami, K, Yoshida, S, Nishimori, K, Nishijima, I, Sakamoto, H, Yamagata, T & Onaka, T 2015, 'Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2015.11.021
Takayanagi, Yuki ; Yoshida, Masahide ; Takashima, Akihide ; Takanami, Keiko ; Yoshida, Shoma ; Nishimori, Katsuhiko ; Nishijima, Ichiko ; Sakamoto, Hirotaka ; Yamagata, Takanori ; Onaka, Tatsushi. / Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition. In: Biological Psychiatry. 2015.
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AU - Takanami, Keiko

AU - Yoshida, Shoma

AU - Nishimori, Katsuhiko

AU - Nishijima, Ichiko

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AU - Onaka, Tatsushi

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