Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates

H. Hayatsu, H. Shimada, Sakae Arimoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalGann, The Japanese Journal of Cancer Research
Volume75
Issue number3
Publication statusPublished - 1984

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N-nitrosopiperidine
N-Nitrosopyrrolidine
Phosphates
Salmonella typhimurium
Ultraviolet Rays
Esters
Adenosine Triphosphate
N-nitrosomorpholine
Metabolic Activation

ASJC Scopus subject areas

  • Cancer Research

Cite this

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title = "Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates",
abstract = "When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.",
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AU - Hayatsu, H.

AU - Shimada, H.

AU - Arimoto, Sakae

PY - 1984

Y1 - 1984

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AB - When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.

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