Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates

H. Hayatsu; H. Shimada; S. Arimoto

Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates

H. Hayatsu, H. Shimada, S. Arimoto

Research output: Contribution to journal › Article › peer-review

Abstract

When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.

Original language	English
Pages (from-to)	203-206
Number of pages	4
Journal	Gann, The Japanese Journal of Cancer Research
Volume	75
Issue number	3
Publication status	Published - Jan 1 1984

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates",

abstract = "When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.",

author = "H. Hayatsu and H. Shimada and S. Arimoto",

year = "1984",

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AU - Hayatsu, H.

AU - Shimada, H.

AU - Arimoto, S.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.

AB - When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA 100 in the absence of metabolic activation. The formation of the active compounds required the presence of phosphate or its esters such as adenosine 5'-triphosphate during the irradiation.

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Activation of promutagenic N-nitrosomorpholine and other N-nitrosoalkylamines by near-ultraviolet irradiation in the presence of phosphates

Abstract

ASJC Scopus subject areas

UN SDGs

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