Activation of complement during hemodialysis

Y. Nagake, T. Amano, Jun Wada, H. Sugimoto, K. Kawabata, Kenichi Shikata, Hirofumi Makino, Z. Ota

Research output: Contribution to journalArticle

Abstract

In hemodialysis using 3 types of dialysis membrane materials [regenerated cellulose (RC), cellulose triacetate (CTA), and polysulfone (PS)], activation of the complement, reduction of white blood cells, and variation of vitronectin (VN) were observed. RC membrane caused a significant reduction of white blood cells and elevations of Bb and soluble membrane attack complex (S-MAC), indicating a strong activation of the alternative complement pathway. Especially, the increase of S-MAC persisted for a long time during hemodialysis. Because reduction of VN was transient, it was assumed that the S-MAC escaping removal by VN receptors might have persisted in the circulation. These findings suggested that S-MAC would become useful as an index for evaluating biocompatibility of various artificial organs including dialysis membranes.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalNihon Rinsho Men"eki Gakkai kaishi = Japanese journal of clinical immunology
Volume18
Issue number2
Publication statusPublished - Apr 1995

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Complement Membrane Attack Complex
Complement Activation
Renal Dialysis
Vitronectin
Cellulose
Membranes
Vitronectin Receptors
Dialysis
Leukocytes
Artificial Organs
Alternative Complement Pathway

ASJC Scopus subject areas

  • Medicine(all)

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Activation of complement during hemodialysis. / Nagake, Y.; Amano, T.; Wada, Jun; Sugimoto, H.; Kawabata, K.; Shikata, Kenichi; Makino, Hirofumi; Ota, Z.

In: Nihon Rinsho Men"eki Gakkai kaishi = Japanese journal of clinical immunology, Vol. 18, No. 2, 04.1995, p. 138-145.

Research output: Contribution to journalArticle

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AU - Amano, T.

AU - Wada, Jun

AU - Sugimoto, H.

AU - Kawabata, K.

AU - Shikata, Kenichi

AU - Makino, Hirofumi

AU - Ota, Z.

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