Activation of complement during hemodialysis

Yoshio Nagake, Tetsuki Amano, Jun Wada, Hikaru Sugimoto, Kenji Kawabata, Kenichi Shikata, Hirofumi Makino, Zensuke Ota

Research output: Contribution to journalArticle

Abstract

In hemodialysis using 3 types of dialysis membrane materials [regenerated cellulose (RC), cellulose triacetate (CTA), and polysulfone (PS)], activation of the complement, reduction of white blood cells, and variation of vitronectin (VN) were observed. RC membrane caused a significant reduction of white blood cells and elevations of Bb and soluble membrane attack complex (S-MAC), indicating a strong activation of the alternative complement pathway. Especially, the increase of S-MAC persisted for a long time during hemodialysis. Because reduction of VN was transient, it was assumed that the S-MAC escaping removal by VN receptors might have persisted in the circulation. These findings suggested that S-MAC would become useful as an index for evaluating biocompatibility of various artificial organs including dialysis membranes.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalJapanese Journal of Clinical Immunology
Volume18
Issue number2
DOIs
Publication statusPublished - Jan 1 1995

Keywords

  • complementsoluble membrane attack complex (S-MAC)
  • dialyzer
  • hemodialysis
  • hemodialysis leukopenia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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